Upstream Bio, Inc. (UPB) stock
UPBNasdaqPharmaceutical PreparationsFiscal year ends December 31
$3.41+0.14 (+4.28%)
Close on Oct 30, 2026Market cap $186.77MP/E –Yield –
Price history
Upstream Bio share prices for every week, newest first. Adjusted for stock splits, not for dividends.
Close, Oct 30, 2026
$3.41
+4.28% on the day
52-week range
$2.68 – $33.68
-89.9% from the high
Change over 52 weeks
-86.8%
From $25.77 on Oct 30, 2025
Average volume
757,862
Shares a day, last 90 sessions
| Week of | Open | High | Low | Close | Change | Volume |
|---|---|---|---|---|---|---|
| Oct 26, 2026 | $2.75 | $3.43 | $2.68 | $3.41 | +24.45% | 5,611,832 |
| Oct 19, 2026 | $2.76 | $3.09 | $2.70 | $2.74 | -0.72% | 7,191,454 |
| Oct 12, 2026 | $4.68 | $4.72 | $2.74 | $2.76 | -41.28% | 6,582,282 |
| Oct 5, 2026 | $5.07 | $5.10 | $4.37 | $4.70 | -6.75% | 7,026,306 |
| Sep 28, 2026 | $5.34 | $5.46 | $4.86 | $5.04 | -5.97% | 4,039,730 |
| Sep 21, 2026 | $5.42 | $5.56 | $4.99 | $5.36 | +0.37% | 2,273,355 |
| Sep 14, 2026 | $5.75 | $5.87 | $5.21 | $5.34 | -6.81% | 2,944,379 |
| Sep 8, 2026 | $6.01 | $6.21 | $5.65 | $5.73 | -4.66% | 2,742,191 |
| Aug 31, 2026 | $6.64 | $6.98 | $5.77 | $6.01 | -10.16% | 3,882,287 |
| Aug 24, 2026 | $7.00 | $7.31 | $6.46 | $6.69 | -4.02% | 2,306,434 |
| Aug 17, 2026 | $7.02 | $7.56 | $6.73 | $6.97 | -1.41% | 2,915,577 |
| Aug 10, 2026 | $7.32 | $7.70 | $6.80 | $7.07 | -2.48% | 3,199,951 |
| Aug 3, 2026 | $6.31 | $7.26 | $6.18 | $7.25 | +14.90% | 4,103,114 |
| Jul 27, 2026 | $6.47 | $6.69 | $6.09 | $6.31 | -1.56% | 2,213,924 |
| Jul 20, 2026 | $6.99 | $7.15 | $6.16 | $6.41 | -8.56% | 2,756,082 |
| Jul 13, 2026 | $7.47 | $7.53 | $6.90 | $7.01 | -6.91% | 1,882,134 |
| Jul 6, 2026 | $7.50 | $8.00 | $7.28 | $7.53 | +0.27% | 2,610,823 |
| Jun 29, 2026 | $6.77 | $7.72 | $6.56 | $7.51 | +11.26% | 2,144,680 |
| Jun 22, 2026 | $6.33 | $6.78 | $6.24 | $6.75 | +8.00% | 3,908,847 |
| Jun 15, 2026 | $6.19 | $6.52 | $5.86 | $6.25 | +2.46% | 2,870,722 |
| Jun 8, 2026 | $7.16 | $7.16 | $5.85 | $6.10 | -13.48% | 4,000,285 |
| Jun 1, 2026 | $8.33 | $8.64 | $6.98 | $7.05 | -15.67% | 3,254,957 |
| May 26, 2026 | $8.44 | $8.55 | $8.11 | $8.36 | -0.12% | 1,833,323 |
| May 18, 2026 | $8.97 | $9.13 | $7.99 | $8.37 | -7.92% | 3,038,951 |
| May 11, 2026 | $9.20 | $9.60 | $8.51 | $9.09 | 0.00% | 3,450,789 |
| May 4, 2026 | $9.34 | $9.57 | $8.69 | $9.09 | -3.30% | 1,701,288 |
| Apr 27, 2026 | $9.22 | $9.65 | $8.97 | $9.40 | +1.08% | 2,439,970 |
| Apr 20, 2026 | $9.98 | $10.09 | $9.06 | $9.30 | -6.91% | 2,526,465 |
| Apr 13, 2026 | $10.45 | $10.64 | $9.68 | $9.99 | -4.77% | 3,425,584 |
| Apr 6, 2026 | $9.49 | $10.67 | $9.31 | $10.49 | +10.42% | 2,839,946 |
| Mar 30, 2026 | $8.53 | $9.64 | $8.29 | $9.50 | +9.57% | 3,284,231 |
| Mar 23, 2026 | $8.71 | $10.43 | $8.10 | $8.67 | 0.00% | 4,001,279 |
| Mar 16, 2026 | $9.29 | $9.90 | $8.16 | $8.67 | -6.07% | 6,116,813 |
| Mar 9, 2026 | $7.65 | $9.76 | $7.64 | $9.23 | +20.50% | 5,399,332 |
| Mar 2, 2026 | $7.51 | $8.01 | $7.25 | $7.66 | -0.26% | 5,485,785 |
| Feb 23, 2026 | $8.09 | $8.32 | $7.62 | $7.68 | -4.95% | 7,085,285 |
| Feb 17, 2026 | $8.69 | $9.00 | $7.93 | $8.08 | -7.66% | 14,440,758 |
| Feb 9, 2026 | $26.24 | $28.58 | $8.52 | $8.75 | -66.60% | 20,541,461 |
| Feb 2, 2026 | $31.10 | $32.38 | $25.87 | $26.20 | -15.70% | 3,166,753 |
| Jan 26, 2026 | $29.77 | $32.83 | $29.61 | $31.08 | +3.53% | 3,399,940 |
| Jan 20, 2026 | $30.22 | $32.52 | $29.08 | $30.02 | -3.16% | 2,015,977 |
| Jan 12, 2026 | $29.73 | $33.68 | $29.34 | $31.00 | +4.20% | 3,271,983 |
| Jan 5, 2026 | $27.07 | $30.60 | $25.00 | $29.75 | +9.90% | 3,197,162 |
| Dec 29, 2025 | $29.48 | $29.92 | $26.72 | $27.07 | -8.18% | 2,174,101 |
| Dec 22, 2025 | $29.29 | $30.89 | $29.00 | $29.48 | +0.44% | 1,543,083 |
| Dec 15, 2025 | $27.56 | $30.56 | $26.03 | $29.35 | +8.14% | 4,804,486 |
| Dec 8, 2025 | $28.03 | $29.55 | $26.78 | $27.14 | -2.20% | 2,058,052 |
| Dec 1, 2025 | $28.32 | $29.89 | $24.61 | $27.75 | -2.97% | 2,723,086 |
| Nov 24, 2025 | $25.35 | $33.00 | $25.32 | $28.60 | +11.94% | 2,594,619 |
| Nov 17, 2025 | $24.39 | $26.20 | $24.10 | $25.55 | +4.16% | 2,321,553 |
| Nov 10, 2025 | $23.52 | $25.10 | $22.59 | $24.53 | +6.84% | 2,413,753 |
| Nov 3, 2025 | $25.92 | $26.22 | $21.98 | $22.96 | -11.18% | 1,455,538 |
| Oct 27, 2025 | $21.97 | $26.90 | $21.89 | $25.85 | +18.25% | 1,598,240 |
| Oct 20, 2025 | $21.37 | $23.34 | $21.02 | $21.86 | +4.24% | 2,141,050 |
| Oct 13, 2025 | $19.79 | $22.39 | $19.56 | $20.97 | +6.88% | 1,726,212 |
| Oct 6, 2025 | $18.72 | $20.68 | $18.18 | $19.62 | +5.31% | 1,762,016 |
| Sep 29, 2025 | $17.23 | $19.23 | $17.06 | $18.63 | +7.94% | 1,895,690 |
| Sep 22, 2025 | $16.40 | $17.32 | $16.00 | $17.26 | +5.37% | 1,233,248 |
| Sep 15, 2025 | $17.83 | $18.00 | $15.55 | $16.38 | -6.77% | 4,297,625 |
| Sep 8, 2025 | $20.08 | $20.32 | $17.02 | $17.57 | -12.02% | 2,088,552 |
| Sep 2, 2025 | $16.87 | $21.03 | $16.66 | $19.97 | +16.58% | 4,281,537 |
| Aug 25, 2025 | $17.60 | $17.78 | $16.37 | $17.13 | -2.84% | 1,576,441 |
| Aug 18, 2025 | $18.93 | $19.37 | $16.02 | $17.63 | -6.87% | 1,992,593 |
| Aug 11, 2025 | $16.00 | $19.28 | $15.64 | $18.93 | +18.31% | 3,252,088 |
| Aug 4, 2025 | $15.59 | $17.57 | $15.04 | $16.00 | +2.96% | 1,723,192 |
| Jul 28, 2025 | $13.73 | $16.15 | $12.95 | $15.54 | +14.01% | 3,180,783 |
| Jul 21, 2025 | $10.73 | $13.97 | $10.54 | $13.63 | +27.15% | 2,656,957 |
| Jul 14, 2025 | $11.44 | $12.10 | $10.63 | $10.72 | -6.62% | 1,599,460 |
| Jul 7, 2025 | $11.15 | $11.97 | $10.75 | $11.48 | +2.50% | 1,610,692 |
| Jun 30, 2025 | $10.91 | $11.50 | $10.60 | $11.20 | +2.47% | 1,072,958 |
| Jun 23, 2025 | $10.88 | $11.58 | $10.41 | $10.93 | +0.46% | 4,619,473 |
| Jun 16, 2025 | $11.46 | $11.61 | $9.82 | $10.88 | -4.23% | 2,210,173 |
| Jun 9, 2025 | $11.52 | $12.10 | $11.10 | $11.36 | +0.80% | 1,694,167 |
| Jun 2, 2025 | $9.29 | $11.52 | $9.25 | $11.27 | +22.10% | 1,945,821 |
| May 26, 2025 | $9.11 | $9.90 | $8.79 | $9.23 | +0.76% | 2,211,956 |
| May 19, 2025 | $8.51 | $9.71 | $8.48 | $9.16 | +6.02% | 1,735,633 |
| May 12, 2025 | $9.00 | $9.70 | $7.99 | $8.64 | -2.04% | 1,409,551 |
| May 5, 2025 | $8.54 | $9.40 | $7.79 | $8.82 | +2.08% | 2,194,874 |
| Apr 28, 2025 | $8.35 | $9.82 | $7.93 | $8.64 | +2.98% | 1,449,717 |
| Apr 21, 2025 | $8.73 | $10.50 | $8.20 | $8.39 | -4.44% | 1,691,025 |
| Apr 14, 2025 | $7.59 | $8.92 | $7.22 | $8.78 | +19.13% | 1,036,179 |
| Apr 7, 2025 | $5.83 | $7.39 | $5.14 | $7.37 | +20.82% | 1,964,788 |
| Mar 31, 2025 | $6.61 | $6.86 | $5.59 | $6.10 | -11.21% | 1,219,084 |
| Mar 24, 2025 | $7.73 | $7.88 | $6.63 | $6.87 | -9.84% | 1,147,729 |
| Mar 17, 2025 | $9.65 | $10.08 | $7.48 | $7.62 | -20.71% | 1,369,035 |
| Mar 10, 2025 | $8.76 | $9.62 | $7.94 | $9.61 | +7.49% | 993,040 |
| Mar 3, 2025 | $8.03 | $9.29 | $6.67 | $8.94 | +12.74% | 1,353,680 |
| Feb 24, 2025 | $7.96 | $8.39 | $7.33 | $7.93 | -0.63% | 1,305,575 |
| Feb 18, 2025 | $7.75 | $8.74 | $7.66 | $7.98 | +5.00% | 625,874 |
| Feb 10, 2025 | $7.98 | $8.36 | $6.65 | $7.60 | -4.04% | 1,232,767 |
| Feb 3, 2025 | $10.42 | $10.65 | $7.70 | $7.92 | -26.46% | 1,732,732 |
| Jan 27, 2025 | $10.24 | $11.80 | $9.29 | $10.77 | +3.66% | 1,112,076 |
| Jan 21, 2025 | $11.01 | $11.34 | $10.24 | $10.39 | -5.55% | 1,111,444 |
| Jan 13, 2025 | $13.35 | $13.37 | $10.36 | $11.00 | -19.71% | 1,249,241 |
| Jan 6, 2025 | $18.53 | $18.95 | $13.42 | $13.70 | -25.34% | 1,085,059 |
| Dec 30, 2024 | $18.70 | $18.74 | $15.67 | $18.35 | -4.38% | 961,857 |
| Dec 23, 2024 | $16.07 | $20.17 | $15.91 | $19.19 | +18.38% | 691,469 |
| Dec 16, 2024 | $19.81 | $20.94 | $14.97 | $16.21 | -19.95% | 5,972,728 |
| Dec 9, 2024 | $24.37 | $24.98 | $19.38 | $20.25 | -15.06% | 1,334,715 |
| Dec 2, 2024 | $21.70 | $24.28 | $20.92 | $23.84 | +9.01% | 1,040,139 |
| Nov 25, 2024 | $18.19 | $22.40 | $18.00 | $21.87 | +20.23% | 679,859 |
| Nov 18, 2024 | $25.42 | $26.70 | $17.09 | $18.19 | -28.55% | 1,576,766 |
| Nov 11, 2024 | $26.42 | $27.87 | $25.24 | $25.46 | -2.75% | 957,352 |
| Nov 4, 2024 | $24.76 | $29.46 | $24.35 | $26.18 | +5.74% | 1,388,218 |
| Oct 28, 2024 | $25.01 | $25.59 | $23.79 | $24.76 | -1.20% | 1,220,497 |
| Oct 21, 2024 | $25.99 | $27.68 | $24.59 | $25.06 | -3.17% | 1,657,635 |
| Oct 14, 2024 | $21.32 | $26.88 | $20.74 | $25.88 | +17.64% | 2,330,834 |
| Oct 11, 2024 | $21.50 | $23.88 | $21.00 | $22.00 | – | 3,576,233 |
Seasonality
UPB return in each calendar month over the last 3 years, including dividends. The current month runs to the latest close.
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Average | -10.0% | -50.8% | -2.8% | 26.7% | -4.6% | 0.9% | 15.3% | 8.4% | -5.3% | 1.1% | -0.6% | -14.9% |
| Months up | 1 of 2 | 0 of 2 | 1 of 2 | 2 of 2 | 0 of 2 | 1 of 2 | 1 of 2 | 2 of 2 | 1 of 2 | 1 of 2 | 1 of 2 | 0 of 2 |
| 2026 | 14.5% | -75.3% | 17.2% | 2.0% | -8.9% | -17.2% | -8.8% | 4.9% | -20.4% | -35.3% | ||
| 2025 | -34.5% | -26.4% | -22.8% | 51.3% | -0.3% | 19.0% | 39.4% | 11.9% | 9.8% | 37.4% | 10.6% | -5.1% |
| 2024 | -11.8% | -24.8% |