Upstream Bio, Inc. (UPB) stock
UPBNasdaqPharmaceutical PreparationsFiscal year ends December 31
$3.41+0.14 (+4.28%)
Close on Oct 30, 2026Market cap $186.77MP/E –Yield –
Price history
Upstream Bio share prices for every month, newest first. Adjusted for stock splits, not for dividends.
Close, Oct 30, 2026
$3.41
+4.28% on the day
52-week range
$2.68 – $33.68
-89.9% from the high
Change over 52 weeks
-86.8%
From $25.77 on Oct 30, 2025
Average volume
757,862
Shares a day, last 90 sessions
| Month | Open | High | Low | Close | Change | Volume |
|---|---|---|---|---|---|---|
| Oct 2026 | $5.25 | $5.35 | $2.68 | $3.41 | -35.29% | 28,200,770 |
| Sep 2026 | $6.58 | $6.98 | $4.99 | $5.27 | -20.39% | 13,198,038 |
| Aug 2026 | $6.31 | $7.70 | $6.18 | $6.62 | +4.91% | 13,420,084 |
| Jul 2026 | $6.90 | $8.00 | $6.09 | $6.31 | -8.82% | 10,387,158 |
| Jun 2026 | $8.33 | $8.64 | $5.85 | $6.92 | -17.22% | 15,255,296 |
| May 2026 | $9.25 | $9.60 | $7.99 | $8.36 | -8.93% | 10,514,049 |
| Apr 2026 | $9.22 | $10.67 | $8.96 | $9.18 | +2.00% | 12,128,649 |
| Mar 2026 | $7.51 | $10.43 | $7.25 | $9.00 | +17.19% | 22,901,058 |
| Feb 2026 | $31.10 | $32.38 | $7.62 | $7.68 | -75.29% | 45,234,257 |
| Jan 2026 | $27.30 | $33.68 | $25.00 | $31.08 | +14.48% | 12,471,501 |
| Dec 2025 | $28.32 | $30.89 | $24.61 | $27.15 | -5.07% | 12,716,369 |
| Nov 2025 | $25.92 | $33.00 | $21.98 | $28.60 | +10.64% | 8,785,463 |
| Oct 2025 | $18.67 | $26.90 | $18.05 | $25.85 | +37.43% | 8,131,745 |
| Sep 2025 | $16.87 | $21.03 | $15.55 | $18.81 | +9.81% | 12,892,425 |
| Aug 2025 | $14.78 | $19.37 | $14.21 | $17.13 | +11.89% | 9,058,422 |
| Jul 2025 | $10.92 | $16.15 | $10.54 | $15.31 | +39.44% | 9,209,914 |
| Jun 2025 | $9.29 | $12.10 | $9.25 | $10.98 | +18.96% | 10,866,462 |
| May 2025 | $9.26 | $9.90 | $7.79 | $9.23 | -0.32% | 8,303,568 |
| Apr 2025 | $6.44 | $10.50 | $5.14 | $9.26 | +51.31% | 6,329,823 |
| Mar 2025 | $8.03 | $10.08 | $6.12 | $6.12 | -22.82% | 5,142,900 |
| Feb 2025 | $10.42 | $10.65 | $6.65 | $7.93 | -26.37% | 4,896,948 |
| Jan 2025 | $16.46 | $18.95 | $9.29 | $10.77 | -34.49% | 5,000,867 |
| Dec 2024 | $21.70 | $24.98 | $14.97 | $16.44 | -24.83% | 9,557,861 |
| Nov 2024 | $25.20 | $29.46 | $17.09 | $21.87 | -11.81% | 4,948,790 |
| Oct 2024 | $21.50 | $27.68 | $20.74 | $24.80 | – | 8,438,604 |
Seasonality
UPB return in each calendar month over the last 3 years, including dividends. The current month runs to the latest close.
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Average | -10.0% | -50.8% | -2.8% | 26.7% | -4.6% | 0.9% | 15.3% | 8.4% | -5.3% | 1.1% | -0.6% | -14.9% |
| Months up | 1 of 2 | 0 of 2 | 1 of 2 | 2 of 2 | 0 of 2 | 1 of 2 | 1 of 2 | 2 of 2 | 1 of 2 | 1 of 2 | 1 of 2 | 0 of 2 |
| 2026 | 14.5% | -75.3% | 17.2% | 2.0% | -8.9% | -17.2% | -8.8% | 4.9% | -20.4% | -35.3% | ||
| 2025 | -34.5% | -26.4% | -22.8% | 51.3% | -0.3% | 19.0% | 39.4% | 11.9% | 9.8% | 37.4% | 10.6% | -5.1% |
| 2024 | -11.8% | -24.8% |