UPBNasdaqPharmaceutical PreparationsFiscal year ends December 31
Upstream Bio, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 11, 2026
$2.80+0.04 (+1.45%)
Close on Oct 19, 2026
- Market cap
- $152.79M
- P/E (TTM)
- –
- Dividend yield
- –
Margins
Share of revenue, fiscal years 2022 to 2025
Operating margin
-5618.8%
Net margin
-5026.0%
Growth rates
Compound annual growth to fiscal 2025
| Per year | 1 year | 3 years | 5 years | 10 years | Five-year pace |
|---|---|---|---|---|---|
| Revenue | +20.4% | – | – | – |
Returns and balance sheet
4 fiscal years. Hover a measure to see how it is calculated.
| Measure | FY2022 | FY2022 | FY2025 | Trend |
|---|---|---|---|---|
| Return on equity | – | – | -35.4% | |
| Return on assets | – | – | -34.3% | |
| Current ratio | – | – | 26.15 | |
| Capex to revenue | – | – | 5.8% | |
| Diluted shares | – | – | 54M |
Cash use needs five years of cash flow figures
Upstream Bio does not report operating cash flow and capital expenditure for each of the last five fiscal years.
DuPont analysis
Return on equity split into margin, efficiency and leverage
Net margin-5026.0%
×Asset turnover0.01×
×Equity multiplier1.03×
=Return on equity, FY2025-35.4%
| Fiscal year | Net margin | Asset turnover | Equity multiplier | Return on equity |
|---|---|---|---|---|
| FY2025 | -5026.0% | 0.01× | 1.03× | -35.4% |
| FY2024 | -2650.0% | 0.01× | 1.73× | -36.2% |
Piotroski F-Score
Nine tests of profitability, balance sheet and efficiency, fiscal 2025 against fiscal 2024
2of 7 tests passed in fiscal 2025. Some tests lack the figures they need.
- ProfitableNet income above zero-$143.44M
- Cash generatingOperating cash flow above zero-$133.28M
- Return on assets improvedROA up on the prior year-53.6% → -29.8%
- Earnings backed by cashOperating cash flow above net income-$133.28M vs -$143.44M
- Less leverageLong-term debt to assets fell– → –
- Better liquidityCurrent ratio rose44.63 → 26.15
- No dilutionShare count did not rise14M → 54M
- Gross margin improvedGross margin up on the prior year– → –
- More efficientAsset turnover rose0.02 → 0.01