Spyre Therapeutics, Inc. (SYRE) stock
SYRENasdaqPharmaceutical PreparationsFiscal year ends December 31
$96.56−2.40 (-2.43%)
Close on Oct 30, 2026Market cap $8.51BP/E –Yield –
Price history
Spyre Therapeutics share prices for every month, newest first. Adjusted for stock splits, not for dividends.
Close, Oct 30, 2026
$96.56
-2.43% on the day
52-week range
$21.15 – $110.18
-12.4% from the high
Change over 52 weeks
+298.0%
From $24.26 on Oct 30, 2025
Average volume
1.25M
Shares a day, last 90 sessions
| Month | Open | High | Low | Close | Change | Volume |
|---|---|---|---|---|---|---|
| Oct 2026 | $89.13 | $100.42 | $76.87 | $96.56 | +8.46% | 29,291,504 |
| Sep 2026 | $87.06 | $95.19 | $82.93 | $89.03 | -0.34% | 26,781,678 |
| Aug 2026 | $97.15 | $110.18 | $86.40 | $89.33 | -9.15% | 21,245,495 |
| Jul 2026 | $88.21 | $105.09 | $85.17 | $98.33 | +10.76% | 24,942,047 |
| Jun 2026 | $72.39 | $102.06 | $68.50 | $88.78 | +20.79% | 37,826,953 |
| May 2026 | $74.09 | $78.80 | $64.67 | $73.50 | -1.28% | 20,685,457 |
| Apr 2026 | $50.33 | $75.00 | $46.27 | $74.45 | +47.60% | 29,850,130 |
| Mar 2026 | $41.27 | $51.06 | $38.36 | $50.44 | +17.28% | 18,285,160 |
| Feb 2026 | $31.76 | $45.76 | $30.92 | $43.01 | +34.49% | 14,652,478 |
| Jan 2026 | $32.76 | $35.07 | $28.00 | $31.98 | -2.38% | 12,331,142 |
| Dec 2025 | $30.55 | $35.31 | $28.16 | $32.76 | +9.20% | 18,752,761 |
| Nov 2025 | $23.95 | $30.21 | $21.15 | $30.00 | +22.65% | 11,836,918 |
| Oct 2025 | $16.73 | $25.06 | $15.86 | $24.46 | +45.94% | 28,945,819 |
| Sep 2025 | $16.26 | $17.58 | $14.51 | $16.76 | +1.64% | 13,714,216 |
| Aug 2025 | $16.50 | $17.80 | $14.72 | $16.49 | -2.83% | 9,674,330 |
| Jul 2025 | $14.86 | $18.31 | $14.00 | $16.97 | +13.36% | 12,609,131 |
| Jun 2025 | $15.40 | $19.20 | $13.93 | $14.97 | -2.03% | 12,703,151 |
| May 2025 | $15.20 | $15.77 | $12.29 | $15.28 | +0.33% | 10,462,195 |
| Apr 2025 | $15.89 | $16.12 | $10.91 | $15.23 | -5.61% | 17,313,258 |
| Mar 2025 | $19.96 | $21.03 | $16.13 | $16.14 | -18.10% | 14,003,695 |
| Feb 2025 | $22.04 | $24.83 | $18.26 | $19.70 | -14.31% | 11,573,853 |
| Jan 2025 | $23.60 | $26.01 | $20.25 | $22.99 | -1.25% | 11,874,416 |
| Dec 2024 | $28.40 | $29.06 | $22.37 | $23.28 | -18.11% | 10,522,943 |
| Nov 2024 | $32.72 | $40.26 | $25.74 | $28.43 | -12.60% | 14,567,842 |
| Oct 2024 | $29.18 | $36.60 | $26.28 | $32.53 | +10.61% | 8,636,201 |
| Sep 2024 | $28.18 | $31.89 | $26.52 | $29.41 | +2.30% | 12,946,429 |
| Aug 2024 | $27.51 | $29.00 | $23.31 | $28.75 | +4.55% | 9,051,156 |
| Jul 2024 | $23.71 | $32.41 | $23.00 | $27.50 | +16.97% | 11,549,318 |
| Jun 2024 | $35.00 | $38.90 | $22.19 | $23.51 | -32.73% | 21,126,345 |
| May 2024 | $33.01 | $40.49 | $31.39 | $34.95 | +5.81% | 6,803,819 |
| Apr 2024 | $37.82 | $40.84 | $31.27 | $33.03 | -12.92% | 7,123,369 |
| Mar 2024 | $30.18 | $47.97 | $28.48 | $37.93 | +38.23% | 14,273,278 |
| Feb 2024 | $25.93 | $28.80 | $20.07 | $27.44 | +5.91% | 9,576,663 |
| Jan 2024 | $21.99 | $28.66 | $18.54 | $25.91 | +20.40% | 6,340,248 |
| Dec 2023 | $18.77 | $22.66 | $14.22 | $21.52 | +15.33% | 3,058,559 |
| Nov 2023 | $11.61 | $19.60 | $8.43 | $18.66 | +60.31% | 1,290,164 |
| Oct 2023 | $12.04 | $15.39 | $9.23 | $11.64 | -4.98% | 994,598 |
| Sep 2023 | $13.75 | $16.58 | $10.22 | $12.25 | -14.78% | 921,285 |
| Aug 2023 | $13.25 | $14.68 | $10.25 | $14.38 | +1.75% | 358,638 |
| Jul 2023 | $11.29 | $18.00 | $9.53 | $14.13 | +25.44% | 2,179,477 |
| Jun 2023 | $3.25 | $24.00 | $2.75 | $11.26 | +246.81% | 13,733,262 |
| May 2023 | $4.25 | $4.43 | $3.13 | $3.25 | -23.00% | 387,329 |
| Apr 2023 | $7.42 | $7.42 | $3.53 | $4.22 | -41.83% | 1,368,636 |
| Mar 2023 | $10.30 | $11.95 | $7.13 | $7.25 | -26.02% | 185,829 |
| Feb 2023 | $12.19 | $14.14 | $8.33 | $9.80 | -21.60% | 257,816 |
| Jan 2023 | $10.88 | $15.50 | $10.00 | $12.50 | +11.14% | 320,423 |
| Dec 2022 | $10.14 | $13.50 | $8.50 | $11.25 | +8.41% | 934,348 |
| Nov 2022 | $26.00 | $39.00 | $9.78 | $10.38 | -59.71% | 1,918,504 |
| Oct 2022 | $13.25 | $28.25 | $11.50 | $25.75 | +95.82% | 2,043,674 |
| Sep 2022 | $13.00 | $13.50 | $10.52 | $13.15 | +0.57% | 280,207 |
| Aug 2022 | $10.25 | $26.00 | $9.30 | $13.08 | +25.90% | 4,637,984 |
| Jul 2022 | $12.62 | $13.73 | $10.00 | $10.39 | -17.76% | 199,916 |
| Jun 2022 | $39.00 | $41.00 | $12.59 | $12.63 | -68.03% | 1,129,810 |
| May 2022 | $35.75 | $40.75 | $32.25 | $39.50 | +9.72% | 367,089 |
| Apr 2022 | $59.00 | $79.25 | $35.88 | $36.00 | -37.39% | 818,269 |
| Mar 2022 | $70.25 | $72.75 | $45.00 | $57.50 | -16.97% | 345,622 |
| Feb 2022 | $109.00 | $113.50 | $66.50 | $69.25 | -35.58% | 181,346 |
| Jan 2022 | $119.75 | $120.75 | $94.50 | $107.50 | -9.47% | 235,560 |
| Dec 2021 | $159.25 | $159.25 | $86.75 | $118.75 | -23.88% | 508,680 |
| Nov 2021 | $184.75 | $198.50 | $149.75 | $156.00 | -14.75% | 134,348 |
| Oct 2021 | $198.50 | $212.50 | $175.25 | $183.00 | -7.92% | 97,302 |
| Sep 2021 | $180.25 | $204.25 | $167.50 | $198.75 | +9.66% | 136,955 |
| Aug 2021 | $154.00 | $187.00 | $145.50 | $181.25 | +18.27% | 111,781 |
| Jul 2021 | $175.00 | $182.50 | $151.00 | $153.25 | -11.93% | 106,138 |
| Jun 2021 | $163.75 | $196.50 | $153.75 | $174.00 | +5.30% | 245,108 |
| May 2021 | $195.00 | $201.75 | $164.25 | $165.25 | -15.04% | 129,664 |
| Apr 2021 | $197.50 | $217.00 | $178.50 | $194.50 | -1.77% | 92,811 |
| Mar 2021 | $186.25 | $219.75 | $175.50 | $198.00 | +6.31% | 211,927 |
| Feb 2021 | $174.50 | $199.50 | $173.75 | $186.25 | +7.19% | 151,900 |
| Jan 2021 | $199.00 | $217.50 | $164.50 | $173.75 | -11.69% | 198,356 |
| Dec 2020 | $220.50 | $244.50 | $186.75 | $196.75 | -8.06% | 202,005 |
| Nov 2020 | $194.00 | $247.50 | $181.50 | $214.00 | +11.46% | 125,101 |
| Oct 2020 | $178.00 | $218.25 | $173.75 | $192.00 | +8.32% | 359,188 |
| Sep 2020 | $181.25 | $199.00 | $165.25 | $177.25 | -2.54% | 235,896 |
| Aug 2020 | $171.75 | $187.50 | $160.75 | $181.88 | +6.20% | 234,200 |
| Jul 2020 | $232.50 | $248.75 | $166.25 | $171.25 | -25.95% | 164,759 |
| Jun 2020 | $219.25 | $284.50 | $187.50 | $231.25 | +4.99% | 396,941 |
| May 2020 | $188.00 | $234.50 | $155.00 | $220.25 | +13.38% | 187,327 |
| Apr 2020 | $112.25 | $196.25 | $100.00 | $194.25 | +66.74% | 187,635 |
| Mar 2020 | $169.25 | $176.00 | $87.50 | $116.50 | -31.77% | 71,395 |
| Feb 2020 | $182.50 | $212.50 | $163.88 | $170.75 | -5.92% | 43,282 |
| Jan 2020 | $185.75 | $201.50 | $167.25 | $181.50 | -4.97% | 42,538 |
| Dec 2019 | $212.50 | $213.00 | $180.51 | $191.00 | -10.64% | 60,092 |
| Nov 2019 | $195.50 | $216.75 | $182.00 | $213.75 | +12.35% | 40,111 |
| Oct 2019 | $191.50 | $203.25 | $176.25 | $190.25 | -1.04% | 32,947 |
| Sep 2019 | $193.75 | $224.00 | $185.25 | $192.25 | -1.47% | 59,036 |
| Aug 2019 | $223.75 | $227.25 | $182.75 | $195.13 | -12.89% | 73,317 |
| Jul 2019 | $172.50 | $227.50 | $158.75 | $224.00 | +30.80% | 130,207 |
| Jun 2019 | $155.75 | $174.73 | $149.75 | $171.25 | +9.78% | 190,596 |
| May 2019 | $171.00 | $177.00 | $153.78 | $156.00 | -8.91% | 83,403 |
| Apr 2019 | $200.00 | $223.00 | $166.35 | $171.25 | -14.91% | 182,058 |
| Mar 2019 | $208.25 | $217.83 | $188.25 | $201.25 | -3.71% | 144,666 |
| Feb 2019 | $228.25 | $236.25 | $180.00 | $209.00 | -8.53% | 181,304 |
| Jan 2019 | $184.50 | $232.25 | $184.50 | $228.50 | +22.03% | 65,048 |
| Dec 2018 | $213.50 | $220.50 | $157.75 | $187.25 | -11.05% | 108,227 |
| Nov 2018 | $217.00 | $241.00 | $186.25 | $210.50 | -2.43% | 93,748 |
| Oct 2018 | $247.75 | $262.25 | $203.01 | $215.75 | -9.82% | 249,222 |
| Sep 2018 | $277.75 | $277.75 | $201.25 | $239.25 | -12.44% | 189,693 |
| Aug 2018 | $210.00 | $279.00 | $210.00 | $273.25 | +29.96% | 127,747 |
| Jul 2018 | $264.50 | $284.25 | $206.00 | $210.25 | -20.51% | 172,954 |
| Jun 2018 | $272.25 | $300.00 | $226.75 | $264.50 | -0.94% | 315,677 |
| May 2018 | $231.50 | $279.75 | $222.00 | $267.00 | +14.35% | 175,778 |
| Apr 2018 | $251.25 | $268.19 | $187.50 | $233.50 | -5.85% | 249,954 |
| Mar 2018 | $181.00 | $283.75 | $170.03 | $248.00 | +36.83% | 94,125 |
| Feb 2018 | $165.75 | $186.40 | $128.00 | $181.25 | +11.88% | 58,678 |
| Jan 2018 | $136.00 | $191.75 | $123.75 | $162.00 | +19.78% | 72,331 |
| Dec 2017 | $101.00 | $147.00 | $100.09 | $135.25 | +35.25% | 57,784 |
| Nov 2017 | $108.50 | $131.50 | $93.75 | $100.00 | -8.68% | 47,359 |
| Oct 2017 | $126.50 | $156.00 | $106.50 | $109.50 | -11.15% | 48,999 |
| Sep 2017 | $104.25 | $128.00 | $96.65 | $123.24 | +19.94% | 30,806 |
| Aug 2017 | $90.00 | $119.00 | $70.25 | $102.75 | +20.53% | 56,910 |
| Jul 2017 | $94.83 | $98.50 | $81.50 | $85.25 | -11.43% | 48,768 |
| Jun 2017 | $105.50 | $112.76 | $82.00 | $96.25 | -8.77% | 67,145 |
| May 2017 | $177.85 | $182.04 | $105.25 | $105.50 | -40.98% | 38,485 |
| Apr 2017 | $187.50 | $193.50 | $163.44 | $178.75 | -4.03% | 21,925 |
| Mar 2017 | $155.75 | $203.50 | $142.00 | $186.25 | +20.16% | 92,935 |
| Feb 2017 | $100.25 | $160.97 | $95.80 | $155.00 | +55.39% | 120,155 |
| Jan 2017 | $109.00 | $135.00 | $91.50 | $99.75 | -8.28% | 28,196 |
| Dec 2016 | $129.75 | $156.75 | $106.75 | $108.75 | -15.86% | 27,612 |
| Nov 2016 | $136.00 | $258.50 | $122.50 | $129.25 | -3.54% | 59,261 |
| Oct 2016 | $162.25 | $184.23 | $131.50 | $134.00 | -16.38% | 18,566 |
| Sep 2016 | $140.00 | $207.50 | $140.00 | $160.25 | +13.65% | 25,988 |
| Aug 2016 | $118.75 | $150.00 | $112.50 | $141.00 | +17.50% | 23,796 |
| Jul 2016 | $145.13 | $145.13 | $97.25 | $120.00 | -1.23% | 22,504 |
| Jun 2016 | $187.50 | $192.50 | $102.50 | $121.50 | -35.20% | 65,760 |
| May 2016 | $224.75 | $251.25 | $167.00 | $187.50 | -14.38% | 64,920 |
| Apr 2016 | $250.00 | $318.75 | $209.00 | $219.00 | – | 129,252 |
Seasonality
SYRE return in each calendar month over the last 10 years, including dividends. The current month runs to the latest close.
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Average | 3.5% | 2.9% | 2.2% | -1.0% | -4.6% | 17.5% | 1.0% | 8.2% | 0.3% | 13.4% | 1.0% | -0.4% |
| Months up | 4 of 10 | 5 of 10 | 5 of 10 | 2 of 10 | 5 of 10 | 5 of 10 | 5 of 10 | 7 of 10 | 5 of 10 | 5 of 10 | 4 of 9 | 4 of 9 |
| 2026 | -2.4% | 34.5% | 17.3% | 47.6% | -1.3% | 20.8% | 10.8% | -9.2% | -0.3% | 8.5% | ||
| 2025 | -1.2% | -14.3% | -18.1% | -5.6% | 0.3% | -2.0% | 13.4% | -2.8% | 1.6% | 45.9% | 22.6% | 9.2% |
| 2024 | 20.4% | 5.9% | 38.2% | -12.9% | 5.8% | -32.7% | 17.0% | 4.5% | 2.3% | 10.6% | -12.6% | -18.1% |
| 2023 | 11.1% | -21.6% | -26.0% | -41.8% | -23.0% | 246.8% | 25.4% | 1.8% | -14.8% | -5.0% | 60.3% | 15.3% |
| 2022 | -9.5% | -35.6% | -17.0% | -37.4% | 9.7% | -68.0% | -17.8% | 25.9% | 0.6% | 95.8% | -59.7% | 8.4% |
| 2021 | -11.7% | 7.2% | 6.3% | -1.8% | -15.0% | 5.3% | -11.9% | 18.3% | 9.7% | -7.9% | -14.8% | -23.9% |
| 2020 | -5.0% | -5.9% | -31.8% | 66.7% | 13.4% | 5.0% | -25.9% | 6.2% | -2.5% | 8.3% | 11.5% | -8.1% |
| 2019 | 22.0% | -8.5% | -3.7% | -14.9% | -8.9% | 9.8% | 30.8% | -12.9% | -1.5% | -1.0% | 12.4% | -10.6% |
| 2018 | 19.8% | 11.9% | 36.8% | -5.8% | 14.3% | -0.9% | -20.5% | 30.0% | -12.4% | -9.8% | -2.4% | -11.0% |
| 2017 | -8.3% | 55.4% | 20.2% | -4.0% | -41.0% | -8.8% | -11.4% | 20.5% | 19.9% | -11.1% | -8.7% | 35.3% |