Karyopharm Therapeutics Inc. (KPTIQ) stock
KPTIQPharmaceutical PreparationsFiscal year ends December 31Also trades as KPTI
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Karyopharm Therapeutics operating margin
Operating margin is operating income as a percentage of revenue.
Karyopharm Therapeutics's operating margin for the twelve months ending Jun 30, 2026 was -56.2%. For fiscal 2025 it was -62.1%, against -82.2% the year before. The highest annual figure on record is -46.8% in fiscal 2021.
Annual operating margin
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| FY2025 | Dec 31, 2025 | -62.1% | +20.1 |
| FY2024 | Dec 31, 2024 | -82.2% | +6.5 |
| FY2023 | Dec 31, 2023 | -88.7% | +1.8 |
| FY2022 | Dec 31, 2022 | -90.5% | −43.7 |
| FY2021 | Dec 31, 2021 | -46.8% | +112.2 |
| FY2020 | Dec 31, 2020 | -159.0% | +303.9 |
| FY2019 | Dec 31, 2019 | -462.9% | +130.1 |
| FY2018 | Dec 31, 2018 | -593.0% | +7540.2 |
| FY2017 | Dec 31, 2017 | -8133.2% | +63770.7 |
| FY2016 | Dec 31, 2016 | -71903.9% | −24273.5 |
| FY2015 | Dec 31, 2015 | -47630.4% | −14509.9 |
| FY2014 | Dec 31, 2014 | -33120.5% | −24347.9 |
| FY2013 | Dec 31, 2013 | -8772.6% | −6266.3 |
| FY2012 | Dec 31, 2012 | -2506.3% | +4277.2 |
| FY2011 | Dec 31, 2011 | -6783.6% | – |
Quarterly operating margin
Change is against the same quarter a year earlier.
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| Q2 FY2026 | Jun 30, 2026 | -67.4% | −3.1 |
| Q1 FY2026 | Mar 31, 2026 | -76.3% | +34.5 |
| Q4 FY2025 | Dec 31, 2025 | -52.4% | +50.1 |
| Q3 FY2025 | Sep 30, 2025 | -34.6% | +33.2 |
| Q2 FY2025 | Jun 30, 2025 | -64.3% | +1.4 |
| Q1 FY2025 | Mar 31, 2025 | -110.8% | −8.9 |
| Q4 FY2024 | Dec 31, 2024 | -102.4% | +9.6 |
| Q3 FY2024 | Sep 30, 2024 | -67.8% | +19.0 |
| Q2 FY2024 | Jun 30, 2024 | -65.7% | +13.0 |
| Q1 FY2024 | Mar 31, 2024 | -101.9% | −22.1 |
| Q4 FY2023 | Dec 31, 2023 | -112.0% | −11.2 |
| Q3 FY2023 | Sep 30, 2023 | -86.8% | −1.5 |
| Q2 FY2023 | Jun 30, 2023 | -78.7% | +29.4 |
| Q1 FY2023 | Mar 31, 2023 | -79.8% | −7.3 |
| Q4 FY2022 | Dec 31, 2022 | -100.9% | −138.1 |
| Q3 FY2022 | Sep 30, 2022 | -85.3% | +30.9 |
| Q2 FY2022 | Jun 30, 2022 | -108.1% | +108.9 |
| Q1 FY2022 | Mar 31, 2022 | -72.6% | +152.6 |
| Q4 FY2021 | Dec 31, 2021 | 37.2% | +142.8 |
| Q3 FY2021 | Sep 30, 2021 | -116.2% | +104.6 |
| Q2 FY2021 | Jun 30, 2021 | -217.0% | −96.7 |
| Q1 FY2021 | Mar 31, 2021 | -225.2% | +35.9 |
| Q4 FY2020 | Dec 31, 2020 | -105.6% | +133.5 |
| Q3 FY2020 | Sep 30, 2020 | -220.8% | +78.8 |
| Q2 FY2020 | Jun 30, 2020 | -120.3% | +318.8 |
| Q1 FY2020 | Mar 31, 2020 | -261.1% | +41624.1 |
| Q4 FY2019 | Dec 31, 2019 | -239.1% | +27651.7 |
| Q3 FY2019 | Sep 30, 2019 | -299.7% | +20266.9 |
| Q2 FY2019 | Jun 30, 2019 | -439.1% | −266.5 |
| Q1 FY2019 | Mar 31, 2019 | -41885.2% | −41495.7 |
| Q4 FY2018 | Dec 31, 2018 | -27890.8% | −25318.9 |
| Q3 FY2018 | Sep 30, 2018 | -20566.5% | +971166.8 |
| Q2 FY2018 | Jun 30, 2018 | -172.6% | +44355.3 |
| Q1 FY2018 | Mar 31, 2018 | -389.4% | +57408.5 |
| Q4 FY2017 | Dec 31, 2017 | -2571.8% | +51057.3 |
| Q2 FY2017 | Jun 30, 2017 | -991733.3% | – |
| Q1 FY2017 | Mar 31, 2017 | -44527.9% | – |
| Q4 FY2016 | Dec 31, 2016 | -57797.9% | – |
| Q3 FY2016 | Sep 30, 2016 | -53629.2% | – |
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