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Septerna, Inc. (SEPN) stock

SEPNNasdaqPharmaceutical PreparationsFiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 9, 2026Score 8/30195% above fair value
$42.60+0.74 (+1.77%)

Close on Nov 13, 2026Market cap $1.99BP/E –Yield –

Septerna statistics

74 measures from SEC filings and the closing price. Hover a name for the formula; the last column is the median of companies in the same industry group.

Important dates

Next earnings
Mar 8, 2027 (estimated, after the close)
Last ex-dividend date
No dividends
Fundamentals through
Sep 30, 2026
Share price as of
Nov 13, 2026

Valuation ratiosIndustry

Market Cap
$1.99B
$272.32M
Enterprise Value
$1.51B
$146.23M
PS Ratio
20.66
3.66
PB Ratio
4.65
2.00
P/TBV Ratio
4.65
2.22

Enterprise valuationIndustry

EV / Sales
15.68
2.57

Share statisticsIndustry

Shares Change (QoQ)
3.82%
0.50%
Float
34M
49M
Shares Held by Insiders
28.1%
11.7%
Shares Held by Institutions
101.6%
56.4%

Short sellingIndustry

Short Interest
3M
–
Short Interest Change
-4.84%
-0.80%
Short % of Float
9.99%
9.01%
Short % of Shares Outstanding
7.18%
6.30%
Days to Cover
11.95
5.15

Stock price statisticsIndustry

52-Week High
$53.34
–
52-Week Low
$18.64
–
20-Day Moving Average
$44.19
–
50-Day Moving Average
$40.46
–
200-Day Moving Average
$33.12
–
Average True Range (14)
$3.40
–
Price Change (1 Week)
-12.8%
-1.15%
Price Change (1 Month)
13.8%
-4.87%
Price Change (3 Months)
-3.62%
-21.0%
Price Change (6 Months)
58.1%
-20.6%
Price Change (YTD)
52.8%
-23.6%
Price Change (1 Year)
121.5%
-22.4%
Average Volume (10 Days)
563,150
–
Average Volume (20 Days)
427,169
–
Average Volume (90 Days)
394,029
–
Relative Volume
0.84
0.70
Relative Strength Index (14)
48.0
43.4
Volatility (1 Year)
69.2%
80.1%
Beta (5 Years)
1.87
1.07

MarginsIndustry

Operating Margin
-76.2%
-38.7%
Pretax Margin
-55.1%
-11.6%
Profit Margin
-61.3%
-31.6%
EBITDA Margin
-74.6%
-27.7%
FCF Margin
-80.6%
-9.56%

Returns on capitalIndustry

Return on Equity (ROE)
-14.4%
-49.9%
Return on Assets (ROA)
-9.62%
-40.6%
Return on Capital Employed (ROCE)
-14.3%
-37.9%

Financial positionIndustry

Current Ratio
4.84
3.30
Quick Ratio
4.74
2.39

GrowthIndustry

Revenue Growth (YoY)
336.7%
6.82%
FCF Growth (YoY)
-175.2%
6.85%

EfficiencyIndustry

Asset Turnover
0.16
0.40
Revenue Per Employee
$740.52K
$429.29K
Profits Per Employee
-$453.84K
-$689.41K
Employee Count
130
74
WACC
14.4%
10.2%

Income statement (TTM)Industry

Revenue
$96.27M
$66.37M
Operating Income
-$73.39M
-$21.37M
Pretax Income
-$53.06M
-$12.95M
Net Income
-$59.00M
-$22.35M
EBITDA
-$71.79M
-$17.21M
EPS (Diluted)
-$1.29
-$0.76

Balance sheetIndustry

Net Cash (Debt)
$478.60M
$17.76M
Net Cash Per Share
$10.25
$0.80
Equity (Book Value)
$427.93M
$53.89M
Book Value Per Share
$9.17
$1.50
Tangible Book Value
$427.93M
$27.13M
Working Capital
$402.49M
$79.99M

Cash flow (TTM)Industry

Operating Cash Flow
-$76.57M
-$12.38M
Capital Expenditures
-$1.02M
-$1.00M
Free Cash Flow
-$77.59M
-$18.21M
FCF Per Share
-$1.66
-$0.42

Dividends and yieldsIndustry

Earnings Yield
-2.97%
-21.8%
FCF Yield
-3.90%
-9.44%

Taxes and interestIndustry

Income Tax
$5.94M
$73.00K

Scores and fair valueIndustry

Altman Z-Score
6.29
0.23
Piotroski F-Score
5
4

Total return vs. the S&P 500

Price change plus reinvested dividends, to the close on Nov 13, 2026. The S&P 500 is measured by the SPY fund.

PeriodSEPNS&P 500DifferenceSEPN per yearS&P 500 per year
1 month+17.0%-3.0%+20.0 pts
3 months-5.6%-2.8%−2.8 pts
Year to date+52.8%+11.5%+41.3 pts
1 year+121.4%+13.5%+108.0 pts

Short interest

Shares sold short and not yet covered, reported by brokers to FINRA twice a month. Latest settlement date Oct 30, 2026.

3M SEPN shares were sold short on Oct 30, 2026, down 4.8% from the previous report, or 9.99% of the shares available to trade. At recent volumes it would take 11.9 days to buy them back. Over the last 20 sessions, 60.9% of the volume reported to FINRA was short selling.

Settlement dateShares shortChangeAvg. daily volumeDays to cover
Oct 30, 20263,352,395-4.8%280,56211.9
Oct 15, 20263,522,956+13.8%461,7507.6
Sep 30, 20263,096,190+7.0%351,8898.8
Sep 15, 20262,894,002+6.5%303,4779.5
Aug 31, 20262,718,332-5.4%355,3877.7
Aug 14, 20262,874,690-18.1%567,9395.1
Jul 31, 20263,507,965+4.7%247,88314.2
Jul 15, 20263,350,617+6.2%585,7515.7
Jun 30, 20263,154,131+18.3%597,7525.3
Jun 15, 20262,665,398+1.8%342,5917.8
May 29, 20262,617,322+9.5%275,1689.5
May 15, 20262,390,125+15.6%321,9017.4

Ratios use trailing-twelve-month results and the latest balance sheet. How we calculate.

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