SPRBNasdaqPharmaceutical PreparationsFiscal year ends December 31
SPRUCE BIOSCIENCES, INC.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 12, 2026
$40.40+0.75 (+1.89%)
Close on Oct 19, 2026
- Market cap
- $98.22M
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
69.7%
2M of 3M shares
Institutional holders
63
35 new, 4 sold out
Net institutional buying
1M
In Q2 2026
Insider trades, 12 months
0 buys · 0 sales
Open-market trades only
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Matthew Sesterhenn | 70,000 | 6.50% | 13G (passive) amendment | Dec 31, 2025 |
| William Blank | 70,000 | 6.60% | 13G (passive) | Oct 8, 2025 |
| Boone Peter David Mr | 68,184 | 6.40% | 13G (passive) | Nov 21, 2025 |
| Daniel Schneeberger | 58,000 | 5.40% | 13G (passive) | Dec 31, 2025 |
| Orin Hirschman | 250,000 | 9.10% | 13G (passive) | Jun 30, 2026 |
| BlackRock, Inc. | 187,836 | 6.80% | 13G (passive) | Jun 30, 2026 |
| Israel A. Englander | 160,981 | 5.80% | 13G (passive) amendment | Jun 30, 2026 |
| AWM Investment Company, Inc. | 146,988 | 5.10% | 13G (passive) | Jun 30, 2026 |
| Neil Shahrestani | 121,356 | 11.40% | 13G (passive) amendment | Oct 31, 2025 |
| Citadel Advisors Holdings LP | 109,649 | 9.99% | 13G (passive) | Oct 9, 2025 |
| Millennium Group Management LLC | 103,026 | 9.60% | 13G (passive) | Feb 17, 2026 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of SPRB | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| AIGH Capital Management LLC | 250,000 | 8.70% | $13.50M | New | 0.85% |
| Orbimed Advisors LLC | 200,000 | 6.96% | $10.80M | New | 0.20% |
| BlackRock, Inc. | 187,836 | 6.54% | $10.14M | +170,898 | 0.00% |
| Millennium Management LLC | 160,981 | 5.60% | $8.69M | +49,093 | 0.00% |
| Ikarian Capital, LLC | 121,356 | 4.22% | $6.55M | – | 0.71% |
| Vanguard Capital Management LLC | 119,331 | 4.15% | $6.44M | +100,994 | 0.00% |
| Alyeska Investment Group, L.P. | 81,671 | 2.84% | $4.41M | +30,000 | 0.01% |
| Geode Capital Management, LLC | 70,548 | 2.45% | $3.81M | +57,659 | 0.00% |
| ADAR1 Capital Management, LLC | 67,717 | 2.36% | $3.66M | +9,117 | 0.17% |
| Cable Car Capital, LP | 60,000 | 2.09% | $3.24M | New | 0.07% |
| Citadel Advisors LLC | 51,905 | 1.81% | $2.80M | −18,094 | 0.00% |
| State Street Corp | 50,450 | 1.76% | $2.72M | +45,050 | 0.00% |
| Boothbay Fund Management, LLC | 42,080 | 1.46% | $2.27M | – | 0.03% |
| Stempoint Capital LP | 41,388 | 1.44% | $2.23M | +28,668 | 0.38% |
| Eversept Partners, LP | 40,000 | 1.39% | $2.16M | New | 0.11% |
| Carlyle Group Inc. | 38,620 | 1.34% | $2.09M | – | 0.02% |
| Goldman Sachs Group Inc | 32,348 | 1.13% | $1.75M | +26,842 | 0.00% |
| Diadema Partners LP | 30,000 | 1.04% | $1.62M | +20,000 | 0.20% |
| Affinity Asset Advisors, LLC | 30,000 | 1.04% | $1.62M | New | 0.07% |
| Stonepine Capital Management, LLC | 28,795 | 1.00% | $1.55M | New | 0.88% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 63 | 2M | 69.7% | 35 / 16 | 3 / 4 | 1M | 0M |
| Q1 2026 | 32 | 1M | 26.0% | 10 / 6 | 6 / 9 | 0M | 0M |
| Q4 2025 | 32 | 1M | 26.2% | 25 / 4 | 1 / 2 | 1M | 3M |
| Q3 2025 | 9 | 3M | 100.0% | 9 / 0 | 0 / 0 | 3M | 0M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of SPRB | Value | % of fund | As of |
|---|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 84,935 | 2.96% | $4.59M | 0.00% | Jun 30, 2026 |
| iShares Russell 2000 ETF | 65,222 | 2.27% | $3.52M | 0.00% | Jun 30, 2026 |
| Vanguard Extended Market Index Fund | 31,892 | 1.11% | $1.72M | 0.00% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 29,694 | 1.03% | $1.27M | 0.00% | Jul 31, 2026 |
| iShares Russell 2000 Value ETF | 16,862 | 0.59% | $910.55K | 0.01% | Jun 30, 2026 |
| iShares Micro-Cap ETF | 8,665 | 0.30% | $467.91K | 0.03% | Jun 30, 2026 |
| Schwab Small-Cap Index Fund | 6,797 | 0.24% | $291.12K | 0.00% | Jul 31, 2026 |
| iShares Russell 2000 Growth ETF | 6,207 | 0.22% | $335.18K | 0.00% | Jun 30, 2026 |
| Fidelity Extended Market Index Fund | 5,566 | 0.19% | $285.37K | 0.00% | May 31, 2026 |
| Master Small Cap Index Series | 4,827 | 0.17% | $260.66K | 0.00% | Jun 30, 2026 |
| Dimensional U.S. Small Cap ETF | 3,751 | 0.13% | $160.66K | 0.00% | Jul 31, 2026 |
| Nuveen Small Cap Blend Index Fund | 3,660 | 0.13% | $156.76K | 0.00% | Jul 31, 2026 |
| Fidelity Small Cap Value Index Fund | 2,837 | 0.10% | $153.20K | 0.01% | Jun 30, 2026 |
| EQ/2000 Managed Volatility Portfolio | 2,787 | 0.10% | $150.50K | 0.00% | Jun 30, 2026 |
| LVIP State Street Small-Cap Index Fund | 2,100 | 0.07% | $113.40K | 0.01% | Jun 30, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Javier B. Szwarcberg | CHIEF EXECUTIVE OFFICER, Director | 19,270 | 0.67% | Jul 9, 2026 |
| Michael G. Grey | Executive Chairman, Director | – | – | May 26, 2026 |
| Douglas Kirk Ways | Interim Chief Medical Officer, Director | 1,250 | 0.04% | Jan 21, 2026 |
| Adrian W. Quartel | Chief Medical Officer | – | – | Jul 29, 2026 |
| Corwin Dale Hooks | Chief Commercial Officer | – | – | Mar 9, 2026 |
| Samir M. Gharib | PRESIDENT AND CFO | 8,263 | 0.29% | Dec 17, 2025 |
| Ralph William Charlton III | CHIEF MEDICAL OFFICER | 150,409 | 5.23% | Dec 20, 2024 |
| Daniel K. Spiegelman | Director | – | – | May 26, 2026 |
| Keli Walbert | Director | – | – | May 26, 2026 |
| Camilla V. Simpson | Director | 334 | 0.01% | May 26, 2026 |
| Percival Barretto-Ko | Director | 0 | – | May 26, 2026 |
| Tiba Aynechi | Director | – | – | Jul 24, 2025 |
| Bali Muralidhar | Director | 1,792,518 | 62.37% | Jul 24, 2025 |
| Healthcare Partners LLC Parkman | 10% owner | 1,051 | 0.04% | Oct 15, 2025 |
| Gregory Martinez | 10% owner | – | – | Oct 15, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Jun 30, 2026 | Award | +266 | $4.53 | $1.20K | 19,270 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 31, 2025 | Award | +4,690 | $4.53 | $21.25K | 19,004 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 15, 2025 | Option exercise | +1,196 | – | – | 14,922 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 15, 2025 | Option exercise | +1,480 | – | – | 14,478 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 15, 2025 | Tax withholding | −608 | $80.67 | $49.05K | 14,314 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 15, 2025 | Tax withholding | −752 | $80.67 | $60.66K | 13,726 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 15, 2025 | Tax withholding | −184 | $80.67 | $14.84K | 8,263 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 15, 2025 | Option exercise | +513 | – | – | 8,447 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 15, 2025 | Tax withholding | −178 | $80.67 | $14.36K | 7,934 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 15, 2025 | Option exercise | +496 | – | – | 8,112 |
| Douglas Kirk Ways Interim Chief Medical Officer, Director | Dec 11, 2025 | Option exercise | +1,250 | – | – | 1,250 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 11, 2025 | Tax withholding | −680 | $88.41 | $60.12K | 7,616 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 11, 2025 | Option exercise | +1,900 | – | – | 8,296 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 11, 2025 | Option exercise | +4,950 | – | – | 15,192 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 11, 2025 | Tax withholding | −2,194 | $88.41 | $193.97K | 12,998 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 10, 2025 | Tax withholding | −184 | $85.67 | $15.76K | 6,396 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 10, 2025 | Option exercise | +514 | – | – | 6,580 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 10, 2025 | Option exercise | +1,196 | – | – | 10,670 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 10, 2025 | Tax withholding | −428 | $85.67 | $36.67K | 10,242 |
| Samir M. Gharib PRESIDENT AND CFO | Oct 20, 2025 | Tax withholding | −661 | $148.16 | $97.93K | 6,066 |
| Samir M. Gharib PRESIDENT AND CFO | Oct 20, 2025 | Option exercise | +2,053 | – | – | 6,727 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Oct 20, 2025 | Tax withholding | −1,539 | $148.16 | $228.02K | 9,474 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Oct 20, 2025 | Option exercise | +4,784 | – | – | 11,013 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Sale | −25 | $17.46 | $437 | 1,050 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Buy | +256 | $17.91 | $4.58K | 1,307 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Sale | −232 | $19.33 | $4.48K | 1,075 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Buy | +256 | $17.91 | $4.58K | 1,307 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Sale | −25 | $17.46 | $437 | 1,050 |
| Healthcare Partners LLC Parkman 10% owner | Oct 6, 2025 | Sale | −232 | $19.33 | $4.48K | 1,075 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 16, 2024 | Option exercise | +26,600 | – | – | 150,409 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 16, 2024 | Option exercise | +31,750 | – | – | 172,668 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 16, 2024 | Tax withholding | −9,491 | $0.39 | $3.70K | 140,918 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 16, 2024 | Tax withholding | −11,329 | $0.39 | $4.42K | 161,339 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 16, 2024 | Tax withholding | −13,291 | $0.39 | $5.18K | 350,550 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 16, 2024 | Option exercise | +38,500 | – | – | 340,328 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 16, 2024 | Option exercise | +37,250 | – | – | 363,841 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 16, 2024 | Tax withholding | −13,737 | $0.39 | $5.36K | 326,591 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 16, 2024 | Option exercise | +89,700 | – | – | 427,801 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 16, 2024 | Tax withholding | −32,005 | $0.39 | $12.48K | 395,796 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 16, 2024 | Option exercise | +111,000 | – | – | 506,796 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 16, 2024 | Tax withholding | −39,605 | $0.39 | $15.45K | 467,191 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 10, 2024 | Option exercise | +106,400 | – | – | 161,773 |
| Ralph William Charlton III CHIEF MEDICAL OFFICER | Dec 10, 2024 | Tax withholding | −37,964 | $0.54 | $20.50K | 123,809 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 10, 2024 | Option exercise | +154,000 | – | – | 356,776 |
| Samir M. Gharib PRESIDENT AND CFO | Dec 10, 2024 | Tax withholding | −54,948 | $0.54 | $29.67K | 301,828 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 10, 2024 | Tax withholding | −128,020 | $0.54 | $69.13K | 338,101 |
| Javier B. Szwarcberg CHIEF EXECUTIVE OFFICER, Director | Dec 10, 2024 | Option exercise | +358,800 | – | – | 466,121 |
| Holdings A/S Novo 10% owner | Mar 21, 2024 | Sale | −465,021 | $0.75 | $348.77K | 2,550,000 |
| Holdings A/S Novo 10% owner | Mar 20, 2024 | Sale | −359,979 | $0.73 | $262.78K | 3,015,021 |
| Holdings A/S Novo 10% owner | Mar 19, 2024 | Sale | −593,000 | $0.76 | $450.68K | 3,375,000 |
| Holdings A/S Novo 10% owner | Mar 18, 2024 | Sale | −842,020 | $0.77 | $648.36K | 3,968,000 |
| Holdings A/S Novo 10% owner | Mar 14, 2024 | Sale | −1,912,316 | $0.89 | $1.70M | 4,810,020 |
| Samir M. Gharib President & CFO | Dec 29, 2023 | Award | +11,255 | $0.98 | $11.03K | 202,776 |
| Ralph William Charlton III Chief Medical Officer | Dec 29, 2023 | Award | +9,361 | $0.98 | $9.17K | 55,373 |
| Javier B. Szwarcberg Chief Executive Officer, Director | Dec 15, 2023 | Option exercise | +111,000 | – | – | 145,705 |
| Javier B. Szwarcberg Chief Executive Officer, Director | Dec 15, 2023 | Tax withholding | −38,384 | $1.66 | $63.72K | 107,321 |
| Ralph William Charlton III Chief Medical Officer | Dec 15, 2023 | Option exercise | +31,750 | – | – | 56,992 |
| Ralph William Charlton III Chief Medical Officer | Dec 15, 2023 | Tax withholding | −10,980 | $1.66 | $18.23K | 46,012 |
| Samir M. Gharib President & CFO | Dec 15, 2023 | Tax withholding | −23,213 | $1.66 | $38.53K | 167,153 |
| Samir M. Gharib President & CFO | Dec 15, 2023 | Option exercise | +75,000 | – | – | 190,366 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Holdings A/S Novo 10% Stockholder | Mar 18, 2024 | 4,810,020 | $3.90M | Mar 18, 2024 | Conversion of Series A Preferred Stock in Initial Public Offering |
| Holdings A/S Novo 10% Stockholder | Mar 14, 2024 | 1,912,316 | $9.49M | Mar 14, 2024 | Conversion of Series A Preferred Stock in Initial Public Offering |