PRMENasdaqBiological Products, (No Diagnostic Substances)Fiscal year ends December 31
Prime Medicine, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 6, 2026
$3.83+0.36 (+10.37%)
Close on Oct 19, 2026
- Market cap
- $678.77M
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
58.8%
107M of 181M shares
Institutional holders
187
23 new, 23 sold out
Net institutional buying
8M
In Q2 2026
Insider trades, 12 months
0 buys · 0 sales
Open-market trades only
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Robert Nelsen | 18,587,036 | 10.40% | 13D (active) amendment | Aug 7, 2025 |
| Alphabet Inc. | 16,562,498 | 12.30% | 13G (passive) amendment | Sep 30, 2025 |
| Bristol-Myers Squibb Company | 11,006,163 | 8.40% | 13G (passive) | Sep 30, 2023 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of PRME | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Alphabet Inc. | 16,562,498 | 9.13% | $61.12M | – | 0.06% |
| BlackRock, Inc. | 9,602,041 | 5.29% | $35.43M | +1,100,333 | 0.00% |
| ARK Investment Management LLC | 8,348,746 | 4.60% | $30.81M | +2,101,919 | 0.20% |
| State Street Corp | 7,576,460 | 4.18% | $27.96M | +1,231,335 | 0.00% |
| T. Rowe Price Investment Management, Inc. | 5,237,332 | 2.89% | $19.33K | −244,561 | 0.01% |
| Vanguard Capital Management LLC | 4,522,640 | 2.49% | $16.69M | +48,478 | 0.00% |
| Balyasny Asset Management L.P. | 3,969,082 | 2.19% | $14.65M | −154,283 | 0.02% |
| Goldman Sachs Group Inc | 3,430,518 | 1.89% | $12.66M | +2,460,093 | 0.00% |
| Casdin Capital, LLC | 3,167,175 | 1.75% | $11.69M | – | 0.58% |
| Woodline Partners LP | 3,003,904 | 1.66% | $11.08M | +591 | 0.03% |
| UBS Group AG | 2,794,689 | 1.54% | $10.31M | −93,729 | 0.00% |
| Geode Capital Management, LLC | 2,712,446 | 1.50% | $10.01M | −31,254 | 0.00% |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,412,984 | 1.33% | $8.90M | −527,809 | 0.01% |
| Nikko Asset Management Americas, Inc. | 2,407,018 | 1.33% | $8.86M | −533,775 | 0.11% |
| Citadel Advisors LLC | 2,054,543 | 1.13% | $7.58M | +1,718,185 | 0.00% |
| ADAR1 Capital Management, LLC | 1,997,552 | 1.10% | $7.37M | +24,270 | 0.34% |
| FMR LLC | 1,761,884 | 0.97% | $6.50M | −7,592 | 0.00% |
| Two Sigma Investments, LP | 1,524,511 | 0.84% | $5.63M | −48,300 | 0.00% |
| Redmile Group, LLC | 1,389,632 | 0.77% | $5.13M | −201,200 | 0.34% |
| Farallon Capital Management LLC | 1,240,843 | 0.68% | $4.58M | – | 0.02% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 187 | 107M | 58.8% | 23 / 64 | 67 / 23 | 14M | 6M |
| Q1 2026 | 192 | 99M | 54.3% | 39 / 73 | 50 / 25 | 17M | 8M |
| Q4 2025 | 183 | 98M | 54.1% | 44 / 66 | 41 / 26 | 26M | 19M |
| Q3 2025 | 167 | 92M | 51.0% | 53 / 63 | 31 / 7 | 38M | 4M |
| Q2 2025 | 121 | 59M | 32.4% | 29 / 36 | 36 / 33 | 8M | 10M |
| Q1 2025 | 125 | 60M | 33.3% | 23 / 42 | 34 / 29 | 2M | 6M |
| Q4 2024 | 132 | 64M | 35.5% | 35 / 39 | 32 / 17 | 3M | 7M |
| Q3 2024 | 116 | 69M | 37.9% | 15 / 38 | 33 / 18 | 9M | 4M |
| Q2 2024 | 122 | 69M | 38.0% | 26 / 45 | 31 / 19 | 7M | 5M |
| Q1 2024 | 115 | 67M | 37.0% | 23 / 40 | 34 / 13 | 19M | 1M |
| Q4 2023 | 105 | 49M | 27.0% | 34 / 26 | 27 / 12 | 4M | 4M |
| Q3 2023 | 83 | 50M | 27.3% | 11 / 35 | 15 / 6 | 5M | 2M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of PRME | Value | % of fund | As of |
|---|---|---|---|---|---|
| ARK Genomic Revolution ETF | 7,513,485 | 4.14% | $21.94M | 1.41% | Jul 31, 2026 |
| State Street(R) SPDR(R) S&P(R) Biotech ETF | 5,226,317 | 2.88% | $19.29M | 0.18% | Jun 30, 2026 |
| Vanguard Total Stock Market Index Fund | 3,120,450 | 1.72% | $11.51M | 0.00% | Jun 30, 2026 |
| iShares Russell 2000 ETF | 2,509,092 | 1.38% | $9.26M | 0.01% | Jun 30, 2026 |
| T. Rowe Price Small-Cap Value Fund, Inc. | 1,357,362 | 0.75% | $5.01M | 0.05% | Jun 30, 2026 |
| Vanguard Extended Market Index Fund | 1,300,373 | 0.72% | $4.80M | 0.00% | Jun 30, 2026 |
| T. Rowe Price Small-Cap Stock Fund, Inc. | 1,219,872 | 0.67% | $4.50M | 0.05% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 1,023,465 | 0.56% | $2.99M | 0.01% | Jul 31, 2026 |
| T. Rowe Price Institutional Small-Cap Stock Fund | 783,011 | 0.43% | $2.89M | 0.06% | Jun 30, 2026 |
| iShares Russell 2000 Growth ETF | 723,775 | 0.40% | $2.67M | 0.02% | Jun 30, 2026 |
| iShares Biotechnology ETF | 670,021 | 0.37% | $2.47M | 0.03% | Jun 30, 2026 |
| Fidelity Extended Market Index Fund | 569,953 | 0.31% | $2.02M | 0.00% | May 31, 2026 |
| Vanguard Russell 2000 Index Fund | 527,260 | 0.29% | $1.87M | 0.01% | May 31, 2026 |
| Schwab U.S. Small-Cap ETF | 520,855 | 0.29% | $1.85M | 0.01% | May 31, 2026 |
| iShares Micro-Cap ETF | 312,342 | 0.17% | $1.15M | 0.08% | Jun 30, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Allan Reine | Chief Executive Officer, Director | 125,000 | 0.07% | Feb 27, 2026 |
| Keith Michael Gottesdiener | See Remarks, Director | 4,361,078 | 2.40% | May 12, 2025 |
| Svetlana Ni Makhni | Chief Financial Officer | – | – | Apr 17, 2026 |
| Carman Alenson | See Remarks | – | – | Feb 24, 2026 |
| Ann L. Lee | Chief Technical Officer | 100,000 | 0.06% | Feb 24, 2026 |
| Richard Brudnick | Chief Business Officer | 20,000 | 0.01% | May 22, 2025 |
| Meredith Goldwasser | SVP, Strategy & Corporate Ops. | 176,917 | 0.10% | Mar 3, 2025 |
| Jeremy Duffield | Chief Scientific Officer | 965,001 | 0.53% | Mar 3, 2025 |
| Wendy Chung | Director | – | – | Jun 8, 2026 |
| Robert Nelsen | Director, 10% owner | 18,502,974 | 10.20% | Jun 8, 2026 |
| Kaye I. Foster-Cheek | Director | – | – | Jun 8, 2026 |
| David P. Schenkein | Director | – | – | Jun 8, 2026 |
| Michael Aaron Kelly | Director | – | – | Jun 8, 2026 |
| Thomas Cahill | Director | 5,305,679 | 2.93% | Jun 8, 2026 |
| Jeffrey D. Marrazzo | Director | – | – | Jun 8, 2026 |
| Inc. Alphabet | 10% owner | 3,262,440 | 1.80% | Aug 5, 2025 |
| Gv 2021, L.P. | 10% owner | 12,497,764 | 6.89% | Aug 5, 2025 |
| Gv 2021 Gp, L.L.C. | 10% owner | 12,153,269 | 6.70% | Aug 5, 2025 |
| Gv 2021 Gp, L.P. | 10% owner | 11,862,498 | 6.54% | Aug 5, 2025 |
| ARCH Venture Fund X, L.P. | 10% owner | – | – | Aug 1, 2025 |
| ARCH Venture Partners XII, LLC | 10% owner | 15,456,594 | 8.52% | Aug 1, 2025 |
| Keith Crandell | 10% owner | – | – | Aug 1, 2025 |
| ARCH Venture Partners X Overage, L.P. | 10% owner | – | – | Aug 1, 2025 |
| Kristina Burow | 10% owner | – | – | Aug 1, 2025 |
| ARCH Venture Fund X Overage, L.P. | 10% owner | – | – | Aug 1, 2025 |
| ARCH Venture Fund XII, L.P. | 10% owner | 18,486,894 | 10.19% | Aug 1, 2025 |
| ARCH Venture Partners X, LLC | 10% owner | 11,856,594 | 6.54% | Aug 1, 2025 |
| ARCH Venture Partners XII, L.P. | 10% owner | – | – | Aug 1, 2025 |
| Steven Gillis | 10% owner | 18,486,894 | 10.19% | Aug 1, 2025 |
| ARCH Venture Partners X, L.P. | 10% owner | 15,456,594 | 8.52% | Aug 1, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Inc. Alphabet 10% owner | Aug 1, 2025 | Buy | +1,500,000 | $3.30 | $4.95M | 3,262,440 |
| Robert Nelsen Director, 10% owner | Aug 1, 2025 | Buy | +3,030,300 | $3.30 | $10.00M | 6,230,300 |
| Steven Gillis 10% owner | Aug 1, 2025 | Buy | +3,030,300 | $3.30 | $10.00M | 6,230,300 |
| ARCH Venture Fund XII, L.P. 10% owner | Aug 1, 2025 | Buy | +3,030,300 | $3.30 | $10.00M | 6,230,300 |
| David R. Liu 10% owner | Jun 30, 2025 | Buy | +21,000 | $2.52 | $52.92K | 20,240,945 |
| David R. Liu 10% owner | Jun 23, 2025 | Buy | +21,000 | $2.16 | $45.36K | 20,219,945 |
| David R. Liu 10% owner | Jun 16, 2025 | Buy | +21,000 | $1.49 | $31.29K | 20,198,945 |
| David R. Liu 10% owner | Jun 11, 2025 | Buy | +21,000 | $1.60 | $33.60K | 20,177,945 |
| Ann L. Lee Chief Technical Officer | May 21, 2025 | Buy | +100,000 | $1.13 | $113.00K | 100,000 |
| Allan Reine Chief Executive Officer, Director | May 21, 2025 | Buy | +125,000 | $1.18 | $147.50K | 125,000 |
| Richard Brudnick Chief Business Officer | May 20, 2025 | Buy | +20,000 | $1.19 | $23.80K | 20,000 |
| Keith Michael Gottesdiener See Remarks, Director | Oct 8, 2024 | Gift | +226,925 | – | – | 682,259 |
| Keith Michael Gottesdiener See Remarks, Director | Oct 8, 2024 | Gift | −226,925 | – | – | 50,241 |
| Keith Michael Gottesdiener See Remarks, Director | Jun 5, 2024 | Gift | −250,000 | – | – | 2,310,837 |
| Keith Michael Gottesdiener See Remarks, Director | Jun 5, 2024 | Gift | +250,000 | – | – | 277,166 |
| ARCH Venture Partners XII, LLC 10% owner | Feb 15, 2024 | Buy | +3,200,000 | $6.25 | $20.00M | 3,200,000 |
| Robert Nelsen Director, 10% owner | Feb 15, 2024 | Buy | +3,200,000 | $6.25 | $20.00M | 3,200,000 |
| ARCH Venture Partners X, L.P. 10% owner | Feb 15, 2024 | Buy | +3,200,000 | $6.25 | $20.00M | 3,200,000 |
| Keith Michael Gottesdiener See Remarks, Director | Nov 11, 2023 | Gift | −5,000 | – | – | 27,166 |
| Keith Michael Gottesdiener See Remarks, Director | Nov 11, 2023 | Gift | −7,500 | – | – | 2,560,837 |
| David R. Liu 10% owner | Jul 21, 2023 | Gift | −1,000,000 | – | – | 20,156,945 |
| David R. Liu 10% owner | Jul 21, 2023 | Gift | −1,000,000 | – | – | 20,156,945 |
| Gv 2021 Gp, L.P. 10% owner | Jun 21, 2023 | Sale(10b5-1 plan) | −19,003 | $14.97 | $284.47K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 21, 2023 | Other | −19,003 | – | – | 10,100,058 |
| Gv 2021 Gp, L.P. 10% owner | Jun 20, 2023 | Other | −37,405 | – | – | 10,119,061 |
| Gv 2021 Gp, L.P. 10% owner | Jun 20, 2023 | Sale(10b5-1 plan) | −37,405 | $15.06 | $563.32K | 0 |
| Inc. Alphabet 10% owner | Jun 16, 2023 | Other | −6,532 | – | – | 10,156,466 |
| Inc. Alphabet 10% owner | Jun 16, 2023 | Sale(10b5-1 plan) | −6,532 | $15.02 | $98.11K | 0 |
| Inc. Alphabet 10% owner | Jun 15, 2023 | Sale(10b5-1 plan) | −66,659 | $14.92 | $994.55K | 0 |
| Inc. Alphabet 10% owner | Jun 15, 2023 | Other | −66,659 | – | – | 10,162,998 |
| Gv 2021 Gp, L.P. 10% owner | Jun 14, 2023 | Sale(10b5-1 plan) | −28,960 | $14.87 | $430.64K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 14, 2023 | Other | −28,960 | – | – | 10,229,657 |
| Gv 2021 Gp, L.P. 10% owner | Jun 13, 2023 | Other | −28,100 | – | – | 10,258,617 |
| Gv 2021 Gp, L.P. 10% owner | Jun 13, 2023 | Sale(10b5-1 plan) | −28,100 | $15.13 | $425.15K | 0 |
| Gv 2019 Gp, L.L.C. 10% owner | Jun 12, 2023 | Sale(10b5-1 plan) | −16,031 | $14.98 | $240.14K | 0 |
| Gv 2019 Gp, L.L.C. 10% owner | Jun 12, 2023 | Other | −16,031 | – | – | 10,286,717 |
| Gv 2019 Gp, L.L.C. 10% owner | Jun 9, 2023 | Other | −15,672 | – | – | 10,302,748 |
| Gv 2019 Gp, L.L.C. 10% owner | Jun 9, 2023 | Sale(10b5-1 plan) | −15,672 | $14.48 | $226.93K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 8, 2023 | Sale(10b5-1 plan) | −5,000 | $15.74 | $78.70K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 8, 2023 | Other | −5,000 | – | – | 10,318,420 |
| Gv 2021 Gp, L.P. 10% owner | Jun 7, 2023 | Other | −15,000 | – | – | 10,323,420 |
| Gv 2021 Gp, L.P. 10% owner | Jun 7, 2023 | Sale(10b5-1 plan) | −15,000 | $16.92 | $253.80K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 6, 2023 | Other | −29,975 | – | – | 10,338,420 |
| Gv 2021 Gp, L.P. 10% owner | Jun 6, 2023 | Sale(10b5-1 plan) | −29,975 | $17.02 | $510.17K | 0 |
| Gv 2021 Gp, L.P. 10% owner | Jun 5, 2023 | Other | −22,434 | – | – | 10,368,395 |
| Gv 2021 Gp, L.P. 10% owner | Jun 5, 2023 | Sale(10b5-1 plan) | −22,434 | $16.70 | $374.65K | 0 |
| Gv 2021 Gp, L.L.C. 10% owner | Jun 1, 2023 | Other | −45,223 | – | – | 10,390,829 |
| Gv 2021 Gp, L.L.C. 10% owner | Jun 1, 2023 | Sale(10b5-1 plan) | −471 | $14.75 | $6.95K | 0 |
| Gv 2021 Gp, L.L.C. 10% owner | Jun 1, 2023 | Sale(10b5-1 plan) | −44,752 | $14.35 | $642.19K | 471 |
| Gv 2021 Gp, L.L.C. 10% owner | May 31, 2023 | Other | −16,633 | – | – | 10,436,052 |
| Gv 2021 Gp, L.L.C. 10% owner | May 31, 2023 | Sale(10b5-1 plan) | −16,633 | $13.65 | $227.04K | 0 |
| Gv 2019 Gp, L.L.C. 10% owner | May 30, 2023 | Sale(10b5-1 plan) | −16,805 | $13.70 | $230.23K | 0 |
| Gv 2019 Gp, L.L.C. 10% owner | May 30, 2023 | Other | −16,805 | – | – | 10,452,685 |
| Gv 2019 Gp, L.L.C. 10% owner | May 26, 2023 | Sale(10b5-1 plan) | −12,602 | $13.70 | $172.65K | 0 |
| Gv 2019 Gp, L.L.C. 10% owner | May 26, 2023 | Other | −12,602 | – | – | 10,469,490 |
| Inc. Alphabet 10% owner | May 25, 2023 | Other | −23,161 | – | – | 10,482,092 |
| Inc. Alphabet 10% owner | May 25, 2023 | Sale(10b5-1 plan) | −23,161 | $13.38 | $309.89K | 0 |
| Inc. Alphabet 10% owner | May 24, 2023 | Other | −7,900 | – | – | 10,505,253 |
| Inc. Alphabet 10% owner | May 24, 2023 | Sale(10b5-1 plan) | −7,900 | $13.66 | $107.91K | 0 |
| Inc. Alphabet 10% owner | May 23, 2023 | Sale(10b5-1 plan) | −43,939 | $14.74 | $647.66K | 0 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Holdings LLC Alphabet 10% Stockholder | Jun 20, 2023 | 522,561 | $7.79M | Jun 20, 2023 | Stock Purchase |
| Holdings LLC Alphabet 10% Stockholder | Jun 12, 2023 | 159,596 | $2.31M | Jun 12, 2023 | STOCK PURCHASE |
| Holdings LLC Alphabet 10% Stockholder | Jun 5, 2023 | 88,081 | $1.42M | Jun 5, 2023 | Stock Purchase |
| Holdings LLC Alphabet 10% Stockholder | May 30, 2023 | 71,263 | $974.17K | May 30, 2023 | stock purchase |
| Holdings LLC Alphabet 10% Stockholder | May 18, 2023 | 260,156 | $3.39M | May 18, 2023 | STOCK PURCHASE |
| Gv 2019, L.P. 10% Stockholder | May 8, 2023 | 1,121,197 | $16.06M | May 8, 2023 | STOCK PURCHASE |