PRAXNasdaqPharmaceutical PreparationsFiscal year ends December 31
Praxis Precision Medicines, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 6, 2026
$260.17+18.41 (+7.61%)
Close on Oct 19, 2026
- Market cap
- $7.58B
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
100.0%
34M of 28M shares
Institutional holders
309
60 new, 39 sold out
Net institutional buying
5M
In Q2 2026
Insider trades, 12 months
0 buys · 18 sales
Net sold $11.08M
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Adage Capital Partners GP, L.L.C. | 738,666 | 8.40% | 13G (passive) amendment | Dec 31, 2023 |
| Janus Henderson Group PLC | 2,763,859 | 12.30% | 13G (passive) amendment | Sep 30, 2025 |
| FMR LLC | 2,156,343 | 7.70% | 13G (passive) amendment | Mar 31, 2026 |
| Perceptive Advisors LLC | 1,995,986 | 7.20% | 13G (passive) amendment | Dec 31, 2025 |
| Phillip Gross | 1,974,585 | 9.69% | 13G (passive) amendment | Jun 30, 2025 |
| Baker Bros. Advisors LP | 1,753,198 | 6.30% | 13G (passive) | Mar 31, 2026 |
| Cormorant Asset Management, LP | 1,625,000 | 7.72% | 13G (passive) amendment | Jun 30, 2025 |
| Steven A. Cohen | 1,569,309 | 6.10% | 13G (passive) amendment | Dec 31, 2025 |
| Orbis Investment Management Ltd | 1,526,680 | 5.50% | 13G (passive) amendment | Jun 30, 2026 |
| Vanguard Capital Management | 1,419,323 | 5.09% | 13G (passive) | Mar 31, 2026 |
| Joseph Edelman | 1,362,503 | 6.69% | 13G (passive) | Jul 15, 2025 |
| Abigail P. Johnson | 1,353,275 | 5.40% | 13G (passive) | Dec 31, 2025 |
| Robert Atchinson | 1,305,175 | 5.29% | 13G (passive) amendment | Oct 31, 2025 |
| BlackRock, Inc. | 1,302,435 | 7.30% | 13G (passive) | Sep 30, 2024 |
| Venrock Healthcare Capital Partners EG, L.P. | 1,190,340 | 6.10% | 13G (passive) amendment | Dec 31, 2024 |
| Soleus Capital, LLC | 1,017,740 | 5.00% | 13G (passive) | Mar 18, 2025 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of PRAX | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Jupiter Topco LLC | 3,421,374 | 12.25% | $1.15B | New | 0.47% |
| FMR LLC | 2,316,907 | 8.30% | $775.68M | +155,964 | 0.03% |
| BlackRock, Inc. | 2,292,585 | 8.21% | $767.53M | −32,344 | 0.01% |
| Perceptive Advisors LLC | 2,035,986 | 7.29% | $681.63M | – | 10.23% |
| Baker Bros. Advisors LP | 1,753,198 | 6.28% | $586.95M | – | 2.94% |
| Orbis Allan Gray Ltd | 1,529,788 | 5.48% | $512.16M | −942,692 | 1.76% |
| Vanguard Portfolio Management LLC | 1,335,185 | 4.78% | $447.01M | +578,437 | 0.02% |
| Vanguard Capital Management LLC | 1,235,299 | 4.42% | $413.57M | +13,355 | 0.01% |
| State Street Corp | 1,026,443 | 3.68% | $343.66M | +142,205 | 0.01% |
| Adage Capital Partners Gp, L.L.C. | 1,015,480 | 3.64% | $339.97M | +199,741 | 0.48% |
| Deerfield Management Company, L.P. (Series C) | 963,351 | 3.45% | $322.52M | – | 3.36% |
| Driehaus Capital Management LLC | 959,048 | 3.43% | $321.08M | +9,823 | 1.86% |
| Price T Rowe Associates Inc /Md/ | 942,999 | 3.38% | $315.71K | +312,147 | 0.03% |
| Morgan Stanley | 854,112 | 3.06% | $285.95M | +20,621 | 0.02% |
| Geode Capital Management, LLC | 748,039 | 2.68% | $250.48M | +97,135 | 0.01% |
| Cormorant Asset Management, LP | 640,000 | 2.29% | $214.27M | −245,500 | 10.98% |
| Goldman Sachs Group Inc | 548,830 | 1.97% | $183.74M | −161,904 | 0.02% |
| Bank Of America Corp /De/ | 546,930 | 1.96% | $183.11M | +12,326 | 0.01% |
| Invesco Ltd. | 537,548 | 1.93% | $179.97M | +476,151 | 0.01% |
| Hood River Capital Management LLC | 425,167 | 1.52% | $142.34M | +66,549 | 1.03% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 309 | 34M | 100.0% | 60 / 122 | 93 / 39 | 8M | 3M |
| Q1 2026 | 291 | 32M | 100.0% | 80 / 120 | 69 / 33 | 7M | 3M |
| Q4 2025 | 250 | 29M | 100.0% | 115 / 87 | 44 / 15 | 10M | 5M |
| Q3 2025 | 152 | 25M | 88.5% | 28 / 59 | 45 / 19 | 5M | 4M |
| Q2 2025 | 143 | 24M | 86.6% | 25 / 65 | 35 / 32 | 5M | 4M |
| Q1 2025 | 150 | 23M | 84.0% | 34 / 47 | 52 / 45 | 6M | 4M |
| Q4 2024 | 162 | 22M | 77.8% | 38 / 55 | 53 / 10 | 5M | 2M |
| Q3 2024 | 134 | 19M | 67.6% | 35 / 43 | 45 / 13 | 5M | 4M |
| Q2 2024 | 113 | 18M | 66.0% | 38 / 42 | 26 / 35 | 6M | 4M |
| Q1 2024 | 111 | 16M | 57.9% | 60 / 29 | 17 / 7 | 10M | 2M |
| Q4 2023 | 58 | 8M | 28.4% | 58 / 0 | 0 / 0 | 8M | 0M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of PRAX | Value | % of fund | As of |
|---|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 885,411 | 3.17% | $296.43M | 0.01% | Jun 30, 2026 |
| iShares Russell 2000 ETF | 653,110 | 2.34% | $218.65M | 0.26% | Jun 30, 2026 |
| Vanguard Small-Cap Index Fund | 639,578 | 2.29% | $214.12M | 0.11% | Jun 30, 2026 |
| State Street(R) SPDR(R) S&P(R) Biotech ETF | 413,737 | 1.48% | $138.52M | 1.29% | Jun 30, 2026 |
| Vanguard Small-Cap Value Index Fund | 405,016 | 1.45% | $135.60M | 0.20% | Jun 30, 2026 |
| Janus Henderson Global Life Sciences Fund | 379,352 | 1.36% | $127.00M | 2.19% | Jun 30, 2026 |
| Select Biotechnology Portfolio | 371,429 | 1.33% | $129.99M | 2.47% | May 31, 2026 |
| Janus Henderson Enterprise Fund | 358,092 | 1.28% | $119.89M | 0.54% | Jun 30, 2026 |
| Vanguard Extended Market Index Fund | 300,868 | 1.08% | $100.73M | 0.10% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 274,766 | 0.98% | $84.58M | 0.25% | Jul 31, 2026 |
| Janus Henderson Triton Fund | 247,753 | 0.89% | $82.95M | 1.40% | Jun 30, 2026 |
| T. Rowe Price New Horizons Fund, Inc. | 236,569 | 0.85% | $79.20M | 0.54% | Jun 30, 2026 |
| iShares Russell 2000 Growth ETF | 233,232 | 0.84% | $78.08M | 0.51% | Jun 30, 2026 |
| Fidelity Small Cap Growth Fund | 186,930 | 0.67% | $57.54M | 0.65% | Jul 31, 2026 |
| iShares Biotechnology ETF | 185,012 | 0.66% | $61.94M | 0.68% | Jun 30, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Marcio Souza | Chief Executive Officer, Director | 56,495 | 0.20% | Jul 8, 2026 |
| Timothy Edwin Kelly | Chief Financial Officer | 31,167 | 0.11% | May 19, 2026 |
| Megan Sniecinski | Chief Operating Officer | 28,664 | 0.10% | May 19, 2026 |
| Lauren Mastrocola | Principal Accounting Officer | 13,573 | 0.05% | May 19, 2026 |
| Alex Nemiroff | General Counsel and Secretary | 26,011 | 0.09% | May 19, 2026 |
| Jill DeSimone | Director | 13,807 | 0.05% | Jun 26, 2026 |
| Merit Ester Cudkowicz | Director | 1,371 | 0.00% | Jun 12, 2026 |
| Jeffrey B. Kindler | Director | 2,537 | 0.01% | Jun 12, 2026 |
| William D. Young | Director | 3,269 | 0.01% | Jun 12, 2026 |
| Stuart A. Arbuckle | Director | 2,537 | 0.01% | Jun 12, 2026 |
| Gregory Norden | Director | 1,559 | 0.01% | Jun 12, 2026 |
| Dean J. Mitchell | Director | 18,622 | 0.07% | Jun 12, 2026 |
| Jeffrey Chodakewitz | Director | 1,371 | 0.00% | Jun 12, 2026 |
| Robert Atchinson | 10% owner | 2,374,085 | 8.50% | Oct 17, 2025 |
| Phillip Gross | 10% owner | 2,080,168 | 7.45% | Oct 17, 2025 |
| Adage Capital Management, L.P. | 10% owner | – | – | Oct 17, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Marcio Souza Chief Executive Officer, Director | Jul 8, 2026 | Gift | −2,600 | – | – | 0 |
| Marcio Souza Chief Executive Officer, Director | Jul 8, 2026 | Gift | −20,521 | – | – | 56,495 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −120 | $303.13 | $36.38K | 13,807 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −320 | $305.31 | $97.70K | 13,487 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −683 | $306.77 | $209.52K | 12,804 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −1,240 | $308.24 | $382.22K | 11,564 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −999 | $309.38 | $309.07K | 10,565 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −1,750 | $310.89 | $544.06K | 8,815 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −2,854 | $311.91 | $890.19K | 5,961 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −1,004 | $312.83 | $314.08K | 4,957 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −504 | $313.66 | $158.08K | 4,453 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −837 | $315.71 | $264.25K | 2,337 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −1,279 | $314.90 | $402.76K | 3,174 |
| Jill DeSimone Director | Jun 24, 2026 | Option exercise | +8,566 | $44.25 | $379.05K | 10,903 |
| Jill DeSimone Director | Jun 24, 2026 | Option exercise | +3,034 | $147.30 | $446.91K | 13,937 |
| Jill DeSimone Director | Jun 24, 2026 | Sale(10b5-1 plan) | −10 | $301.44 | $3.01K | 13,927 |
| Gregory Norden Director | Jun 10, 2026 | Award | +1,371 | – | – | 1,559 |
| Stuart A. Arbuckle Director | Jun 10, 2026 | Award | +1,371 | – | – | 2,537 |
| Jeffrey Chodakewitz Director | Jun 10, 2026 | Award | +1,371 | – | – | 1,371 |
| Jill DeSimone Director | Jun 10, 2026 | Award | +1,371 | – | – | 2,337 |
| Merit Ester Cudkowicz Director | Jun 10, 2026 | Award | +1,371 | – | – | 1,371 |
| William D. Young Director | Jun 10, 2026 | Award | +1,371 | – | – | 3,269 |
| Jeffrey B. Kindler Director | Jun 10, 2026 | Award | +1,371 | – | – | 2,537 |
| Dean J. Mitchell Director | Jun 10, 2026 | Award | +1,371 | – | – | 18,622 |
| Megan Sniecinski Chief Operating Officer | May 14, 2026 | Award | +89 | $167.94 | $14.95K | 28,664 |
| Marcio Souza Chief Executive Officer, Director | May 14, 2026 | Award | +126 | $167.94 | $21.16K | 77,016 |
| Timothy Edwin Kelly Chief Financial Officer | May 14, 2026 | Award | +121 | $167.94 | $20.32K | 31,167 |
| Alex Nemiroff General Counsel and Secretary | May 14, 2026 | Award | +78 | $167.94 | $13.10K | 26,011 |
| Lauren Mastrocola Principal Accounting Officer | May 14, 2026 | Award | +127 | $167.94 | $21.33K | 13,573 |
| Jeffrey B. Kindler Director | Feb 6, 2026 | Award | +688 | – | – | 688 |
| Jeffrey B. Kindler Director | Feb 6, 2026 | Award | +478 | – | – | 1,166 |
| Stuart A. Arbuckle Director | Feb 6, 2026 | Award | +478 | – | – | 1,166 |
| Stuart A. Arbuckle Director | Feb 6, 2026 | Award | +688 | – | – | 688 |
| Megan Sniecinski Chief Operating Officer | Jan 12, 2026 | Tax withholding | −885 | $275.74 | $244.03K | 28,530 |
| Alex Nemiroff General Counsel and Secretary | Jan 12, 2026 | Tax withholding | −768 | $275.74 | $211.77K | 25,933 |
| Lauren Mastrocola Principal Accounting Officer | Jan 12, 2026 | Tax withholding | −344 | $275.74 | $94.85K | 13,446 |
| Timothy Edwin Kelly Chief Financial Officer | Jan 12, 2026 | Tax withholding | −943 | $275.74 | $260.02K | 31,046 |
| Lauren Mastrocola Principal Accounting Officer | Jan 10, 2026 | Tax withholding | −367 | $288.45 | $105.86K | 13,790 |
| Timothy Edwin Kelly Chief Financial Officer | Jan 10, 2026 | Tax withholding | −1,335 | $288.45 | $385.08K | 31,989 |
| Megan Sniecinski Chief Operating Officer | Jan 10, 2026 | Tax withholding | −1,087 | $288.45 | $313.55K | 29,415 |
| Alex Nemiroff General Counsel and Secretary | Jan 10, 2026 | Tax withholding | −917 | $288.45 | $264.51K | 26,701 |
| Marcio Souza Chief Executive Officer, Director | Jan 10, 2026 | Tax withholding | −4,252 | $288.45 | $1.23M | 76,890 |
| Lauren Mastrocola Principal Accounting Officer | Jan 8, 2026 | Award | +3,750 | – | – | 14,157 |
| Timothy Edwin Kelly Chief Financial Officer | Jan 8, 2026 | Award | +8,800 | – | – | 33,324 |
| Megan Sniecinski Chief Operating Officer | Jan 8, 2026 | Award | +9,625 | – | – | 30,502 |
| Alex Nemiroff General Counsel and Secretary | Jan 8, 2026 | Award | +6,875 | – | – | 27,618 |
| Marcio Souza Chief Executive Officer, Director | Jan 8, 2026 | Award | +27,640 | – | – | 81,142 |
| Timothy Edwin Kelly Chief Financial Officer | Jan 7, 2026 | Tax withholding | −139 | $292.63 | $40.68K | 24,524 |
| Alex Nemiroff General Counsel and Secretary | Jan 7, 2026 | Tax withholding | −89 | $292.63 | $26.04K | 20,743 |
| Lauren Mastrocola Principal Accounting Officer | Jan 7, 2026 | Tax withholding | −35 | $292.63 | $10.24K | 10,407 |
| Marcio Souza Chief Executive Officer, Director | Jan 7, 2026 | Tax withholding | −405 | $292.63 | $118.52K | 53,502 |
| Marcio Souza Chief Executive Officer, Director | Dec 30, 2025 | Gift | −400 | – | – | 2,600 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +508 | $83.85 | $42.60K | 11,997 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +1,557 | $133.65 | $208.09K | 13,554 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +2,680 | $43.37 | $116.23K | 16,234 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +207 | $44.40 | $9.19K | 16,441 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +1,047 | $49.50 | $51.83K | 11,489 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +2,351 | $44.40 | $104.38K | 18,792 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Option exercise | +5,250 | $56.94 | $298.94K | 24,042 |
| Lauren Mastrocola Principal Accounting Officer | Nov 20, 2025 | Sale | −11,455 | $191.96 | $2.20M | 12,587 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Jill DeSimone Director | Jun 24, 2026 | 11,600 | $3.61M | Jun 24, 2026 | Stock Option Exercise |
| Lauren Mastrocola Officer | Nov 20, 2025 | 13,600 | $2.61M | Nov 20, 2025 | Option Granted - 09/24/2019 |
| Alex Nemiroff Officer | Nov 20, 2025 | 25,130 | $4.85M | Nov 20, 2025 | Options Granted - 07/29/2024 |
| Lauren Mastrocola Officer | Nov 14, 2024 | 5,189 | $424.32K | Nov 14, 2024 | Option Granted 07/29/2024 |
| Alex Nemiroff Officer | Nov 14, 2024 | 8,240 | $660.83K | Nov 14, 2024 | Options Granted - 07/29/2024 |