OPKNasdaqPharmaceutical PreparationsFiscal year ends December 31
OPKO HEALTH, INC.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q/A on Aug 28, 2026
$1.61+0.08 (+5.23%)
Close on Oct 19, 2026
- Market cap
- $1.22B
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
27.2%
203M of 746M shares
Institutional holders
223
24 new, 31 sold out
Net institutional buying
2M
In Q2 2026
Insider trades, 12 months
34 buys · 0 sales
Net bought $3.21M
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Rubric Capital Management LP | 47,791,243 | 6.03% | 13G (passive) amendment | Jun 30, 2025 |
| Frost Phillip Md Et Al | 255,429,406 | 34.10% | 13D (active) amendment | Jun 29, 2026 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of OPK | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Rubric Capital Management LP | 47,791,243 | 6.40% | $71.69M | – | 0.66% |
| BlackRock, Inc. | 36,978,893 | 4.95% | $55.47M | +746,670 | 0.00% |
| Vanguard Capital Management LLC | 14,968,930 | 2.01% | $22.45M | +469,766 | 0.00% |
| Vanguard Portfolio Management LLC | 14,934,924 | 2.00% | $22.40M | +165,205 | 0.00% |
| Geode Capital Management, LLC | 11,581,027 | 1.55% | $17.38M | +279,526 | 0.00% |
| State Street Corp | 10,309,070 | 1.38% | $15.46M | +807,693 | 0.00% |
| Goldman Sachs Group Inc | 7,035,492 | 0.94% | $10.55M | −639,534 | 0.00% |
| UBS Group AG | 5,006,284 | 0.67% | $7.51M | −1,065,148 | 0.00% |
| Whitefort Capital Management, LP | 4,511,412 | 0.60% | $6.77M | +258,072 | 1.67% |
| Northern Trust Corp | 3,756,163 | 0.50% | $5.63M | +136,817 | 0.00% |
| Charles Schwab Investment Management Inc | 3,596,980 | 0.48% | $5.40M | +22,941 | 0.00% |
| Highbridge Capital Management LLC | 3,593,925 | 0.48% | $5.43M | New | 0.13% |
| Vanguard Fiduciary Trust Co | 2,706,235 | 0.36% | $4.06M | −35,782 | 0.00% |
| AWM Investment Company, Inc. | 2,110,000 | 0.28% | $3.17M | +10,000 | 0.27% |
| Morgan Stanley | 1,975,027 | 0.26% | $2.96M | +778,940 | 0.00% |
| Citadel Advisors LLC | 1,420,922 | 0.19% | $2.13M | −658,625 | 0.00% |
| Washington Growth Strategies LLC | 1,356,124 | 0.18% | $2.03M | – | 1.13% |
| Bank of New York Mellon Corp | 1,329,974 | 0.18% | $1.99M | +49,932 | 0.00% |
| Dimensional Fund Advisors LP | 1,267,741 | 0.17% | $1.90M | −292,259 | 0.00% |
| Y.D. More Investments Ltd | 1,257,568 | 0.17% | $1.88M | −41,905 | 0.06% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 223 | 203M | 27.2% | 24 / 76 | 51 / 31 | 12M | 10M |
| Q1 2026 | 236 | 201M | 27.0% | 44 / 59 | 62 / 23 | 43M | 9M |
| Q4 2025 | 221 | 200M | 26.7% | 30 / 42 | 78 / 33 | 16M | 13M |
| Q3 2025 | 233 | 197M | 26.4% | 30 / 78 | 53 / 15 | 12M | 20M |
| Q2 2025 | 222 | 205M | 27.5% | 17 / 55 | 67 / 48 | 26M | 63M |
| Q1 2025 | 255 | 243M | 32.6% | 44 / 78 | 57 / 23 | 61M | 14M |
| Q4 2024 | 235 | 198M | 26.5% | 35 / 67 | 59 / 29 | 23M | 14M |
| Q3 2024 | 234 | 188M | 25.3% | 36 / 55 | 63 / 31 | 46M | 11M |
| Q2 2024 | 232 | 183M | 24.6% | 39 / 40 | 71 / 27 | 53M | 31M |
| Q1 2024 | 224 | 163M | 21.8% | 43 / 50 | 62 / 35 | 20M | 31M |
| Q4 2023 | 218 | 174M | 23.3% | 25 / 53 | 65 / 32 | 18M | 12M |
| Q3 2023 | 225 | 167M | 22.4% | 24 / 57 | 64 / 26 | 11M | 17M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of OPK | Value | % of fund | As of |
|---|---|---|---|---|---|
| iShares Russell 2000 ETF | 10,477,272 | 1.40% | $15.72M | 0.02% | Jun 30, 2026 |
| Vanguard Total Stock Market Index Fund | 9,753,393 | 1.31% | $14.63M | 0.00% | Jun 30, 2026 |
| Vanguard Small-Cap Index Fund | 6,919,876 | 0.93% | $10.38M | 0.01% | Jun 30, 2026 |
| Vanguard Extended Market Index Fund | 4,914,746 | 0.66% | $7.37M | 0.01% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 4,352,343 | 0.58% | $5.75M | 0.02% | Jul 31, 2026 |
| iShares Russell 2000 Value ETF | 3,827,935 | 0.51% | $5.74M | 0.04% | Jun 30, 2026 |
| iShares Biotechnology ETF | 2,661,460 | 0.36% | $3.99M | 0.04% | Jun 30, 2026 |
| Fidelity Extended Market Index Fund | 2,262,105 | 0.30% | $3.30M | 0.01% | May 31, 2026 |
| Vanguard Small-Cap Value Index Fund | 2,195,148 | 0.29% | $3.29M | 0.00% | Jun 30, 2026 |
| Vanguard Russell 2000 Index Fund | 2,113,129 | 0.28% | $3.09M | 0.02% | May 31, 2026 |
| Schwab U.S. Small-Cap ETF | 2,044,519 | 0.27% | $2.98M | 0.01% | May 31, 2026 |
| Goldman Sachs Small Cap Value Insights Fund | 2,015,781 | 0.27% | $2.66M | 0.20% | Jul 31, 2026 |
| Vanguard Small-Cap Growth Index Fund | 1,985,904 | 0.27% | $2.98M | 0.01% | Jun 30, 2026 |
| Vanguard Health Care Index Fund | 1,261,116 | 0.17% | $1.84M | 0.01% | May 31, 2026 |
| Schwab Small-Cap Index Fund | 984,017 | 0.13% | $1.30M | 0.02% | Jul 31, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Steven D. Rubin | Executive VP-Administration, Director | 26,663,028 | 3.57% | Jul 28, 2026 |
| Phillip Md Et Al Frost | CEO & Chairman, Director, 10% owner | 248,082,576 | 33.24% | Nov 21, 2025 |
| Gary J. Nabel | Chief Innovation Officer, Director | 20,833,727 | 2.79% | May 29, 2025 |
| Elias A. Zerhouni | Vice Chairman and President, Director | 20,367,114 | 2.73% | May 29, 2025 |
| Jane Ph D. Hsiao | Vice Chairman & CTO, Director | 33,627,284 | 4.51% | May 29, 2025 |
| Adam Logal | Sr. Vice President, CFO | 563,396 | 0.08% | Jul 28, 2026 |
| Roger Medel Md | Director | – | – | Jun 22, 2026 |
| Subbarao V. Uppaluri | Director | 3,158,817 | 0.42% | Jun 22, 2026 |
| Richard C. Pfenniger Jr | Director | 325,000 | 0.04% | Jun 22, 2026 |
| Alice Lin-Tsing Yu | Director | 66,490 | 0.01% | Jun 22, 2026 |
| John A. Paganelli | Director | 403,515 | 0.05% | Jun 22, 2026 |
| Prem A. Lachman | Director | 0 | – | Jun 22, 2026 |
| Richard M. Krasno | Director | 103,333 | 0.01% | Apr 23, 2025 |
| Gamma Investments Trust Frost | 10% owner | 250,402,576 | 33.55% | Nov 21, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Steven D. Rubin Executive VP-Administration, Director | Jul 24, 2026 | Tax withholding | −53,266 | $1.22 | $64.98K | 6,571,966 |
| Adam Logal Sr. Vice President, CFO | Jul 24, 2026 | Tax withholding | −53,266 | $1.22 | $64.98K | 563,396 |
| John A. Paganelli Director | Mar 20, 2026 | Buy | +10,000 | $1.14 | $11.40K | 394,340 |
| Gamma Investments Trust Frost 10% owner | Nov 21, 2025 | Buy | +192,870 | $1.34 | $258.45K | 216,706,448 |
| Gamma Investments Trust Frost 10% owner | Nov 21, 2025 | Buy | +102,371 | $1.30 | $133.08K | 216,228,819 |
| Gamma Investments Trust Frost 10% owner | Nov 21, 2025 | Buy | +3,894 | $1.32 | $5.14K | 216,232,713 |
| Gamma Investments Trust Frost 10% owner | Nov 21, 2025 | Buy | +191,490 | $1.33 | $254.68K | 216,513,578 |
| Gamma Investments Trust Frost 10% owner | Nov 21, 2025 | Buy | +89,375 | $1.33 | $118.87K | 216,322,088 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +13,664 | $1.35 | $18.45K | 216,126,448 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +47,105 | $1.33 | $62.65K | 215,712,682 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +119,129 | $1.32 | $157.25K | 215,665,577 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +211,948 | $1.33 | $281.89K | 215,924,630 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +1,757 | $1.35 | $2.37K | 216,112,784 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +24,579 | $1.34 | $32.94K | 216,111,027 |
| Gamma Investments Trust Frost 10% owner | Nov 20, 2025 | Buy | +161,818 | $1.34 | $216.84K | 216,086,448 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +66,504 | $1.31 | $87.12K | 215,192,048 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +12,993 | $1.31 | $17.02K | 215,125,544 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +30,082 | $1.30 | $39.11K | 215,112,551 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +155,496 | $1.32 | $205.25K | 215,546,448 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +300 | $1.29 | $387 | 215,061,233 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +58,160 | $1.29 | $75.03K | 215,060,933 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +36,325 | $1.28 | $46.50K | 215,002,773 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +198,904 | $1.32 | $262.55K | 215,390,952 |
| Gamma Investments Trust Frost 10% owner | Nov 19, 2025 | Buy | +21,236 | $1.30 | $27.61K | 215,082,469 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +428 | $1.28 | $548 | 214,849,319 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +69,728 | $1.28 | $89.25K | 214,848,891 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +83,556 | $1.29 | $107.79K | 214,932,875 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +1 | $1.29 | $1 | 214,932,876 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +33,572 | $1.29 | $43.31K | 214,966,448 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +410 | $1.25 | $513 | 214,386,858 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +49,590 | $1.25 | $61.99K | 214,436,448 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +66,635 | $1.26 | $83.96K | 214,503,083 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Award | +46,700 | $1.26 | $58.84K | 214,549,783 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +15,000 | $1.27 | $19.05K | 214,564,783 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +1,772 | $1.27 | $2.25K | 214,566,555 |
| Gamma Investments Trust Frost 10% owner | Nov 18, 2025 | Buy | +212,608 | $1.28 | $272.14K | 214,779,163 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Oct 31, 2025 | Buy | +150,000 | $1.42 | $213.00K | 214,386,448 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Aug 18, 2025 | Gift | −440,000 | – | – | 214,236,448 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Aug 8, 2025 | Buy | +675,000 | $1.32 | $891.00K | 214,676,448 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Apr 10, 2025 | Buy | +125,000 | $1.36 | $170.00K | 214,001,448 |
| Gamma Investments Trust Frost 10% owner | Apr 8, 2025 | Buy | +125,000 | $1.48 | $185.00K | 213,876,448 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Apr 1, 2025 | Buy | +100,000 | $1.65 | $165.00K | 213,751,448 |
| Gamma Investments Trust Frost 10% owner | Mar 28, 2025 | Buy | +150,000 | $1.70 | $255.00K | 213,651,448 |
| Gamma Investments Trust Frost 10% owner | Mar 17, 2025 | Buy | +200,000 | $1.74 | $348.00K | 213,501,448 |
| Gamma Investments Trust Frost 10% owner | Feb 28, 2025 | Buy | +67,434 | $1.71 | $115.31K | 213,301,448 |
| Gamma Investments Trust Frost 10% owner | Jan 28, 2025 | Buy | +47,537 | $1.47 | $69.88K | 213,234,014 |
| Gamma Investments Trust Frost 10% owner | Jan 17, 2025 | Buy | +150,000 | $1.47 | $220.50K | 213,186,477 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Jan 15, 2025 | Buy | +500,000 | $1.48 | $740.00K | 213,036,477 |
| Gamma Investments Trust Frost 10% owner | Dec 13, 2024 | Buy | +125,000 | $1.60 | $200.00K | 212,536,477 |
| Gamma Investments Trust Frost 10% owner | Dec 11, 2024 | Buy | +500,000 | $1.56 | $780.00K | 212,411,477 |
| Gamma Investments Trust Frost 10% owner | Nov 29, 2024 | Buy | +199,072 | $1.53 | $304.58K | 211,911,477 |
| Gamma Investments Trust Frost 10% owner | Nov 22, 2024 | Buy | +100,000 | $1.59 | $159.00K | 211,712,405 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Nov 14, 2024 | Buy | +100,000 | $1.62 | $162.00K | 211,612,405 |
| Gamma Investments Trust Frost 10% owner | Nov 8, 2024 | Buy | +280,183 | $1.50 | $420.27K | 211,512,405 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Nov 8, 2024 | Buy | +280,183 | $1.50 | $420.27K | 211,512,405 |
| Phillip Md Et Al Frost CEO & Chairman, Director, 10% owner | Jul 24, 2024 | Award | +500,000 | – | – | 3,568,951 |
| Elias A. Zerhouni Vice Chairman and President, Director | Jul 24, 2024 | Award | +500,000 | – | – | 589,600 |
| Jane Ph D. Hsiao Vice Chairman & CTO, Director | Jul 24, 2024 | Award | +500,000 | – | – | 28,499,880 |
| Adam Logal Sr. Vice President, CFO | Jul 24, 2024 | Award | +437,500 | – | – | 616,662 |
| Steven D. Rubin Executive VP-Administration, Director | Jul 24, 2024 | Award | +437,500 | – | – | 6,625,232 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Opko Health, Inc. 10% Stockholder | Jun 28, 2024 | 1,373,525 | $36.49M | Jun 28, 2024 | Compensation for Sale of GeneDX to Sema 4 |