Ionis Pharmaceuticals Inc (IONS) stock
IONSNasdaqPharmaceutical PreparationsFiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 9, 2026Score 3/304% above fair value
$29.06+1.75 (+6.41%)
Close on Nov 13, 2026Market cap $4.83BP/E –Yield –
Ionis Pharmaceuticals profit margin
Profit margin (net margin) is net income as a percentage of revenue.
Ionis Pharmaceuticals's profit margin for the twelve months ending Sep 30, 2026 was -56.9%. For fiscal 2025 it was -40.4%, against -64.4% the year before. The highest annual figure on record is 127.5% in fiscal 2009.
Annual profit margin
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| FY2025 | Dec 31, 2025 | -40.4% | +24.0 |
| FY2024 | Dec 31, 2024 | -64.4% | −17.9 |
| FY2023 | Dec 31, 2023 | -46.5% | −0.6 |
| FY2022 | Dec 31, 2022 | -45.9% | −42.4 |
| FY2021 | Dec 31, 2021 | -3.5% | +57.4 |
| FY2020 | Dec 31, 2020 | -60.9% | −85.7 |
| FY2019 | Dec 31, 2019 | 24.8% | −20.9 |
| FY2018 | Dec 31, 2018 | 45.6% | +45.6 |
| FY2017 | Dec 31, 2017 | 0.1% | +16.3 |
| FY2016 | Dec 31, 2016 | -16.2% | +14.9 |
| FY2015 | Dec 31, 2015 | -31.1% | −12.9 |
| FY2014 | Dec 31, 2014 | -18.2% | +23.0 |
| FY2013 | Dec 31, 2013 | -41.2% | +15.3 |
| FY2010 | Dec 31, 2010 | -56.5% | −184.0 |
| FY2009 | Dec 31, 2009 | 127.5% | +144.5 |
| FY2008 | Dec 31, 2008 | -17.0% | – |
Quarterly profit margin
Change is against the same quarter a year earlier.
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| Q3 FY2026 | Sep 30, 2026 | -45.3% | +36.8 |
| Q2 FY2026 | Jun 30, 2026 | -42.8% | −70.1 |
| Q1 FY2026 | Mar 31, 2026 | -37.6% | +74.0 |
| Q4 FY2025 | Dec 31, 2025 | -112.8% | −66.8 |
| Q3 FY2025 | Sep 30, 2025 | -82.1% | +22.9 |
| Q2 FY2025 | Jun 30, 2025 | 27.3% | +56.7 |
| Q1 FY2025 | Mar 31, 2025 | -111.6% | +7.9 |
| Q4 FY2024 | Dec 31, 2024 | -46.1% | −43.2 |
| Q3 FY2024 | Sep 30, 2024 | -105.0% | −2.8 |
| Q2 FY2024 | Jun 30, 2024 | -29.4% | +15.8 |
| Q1 FY2024 | Mar 31, 2024 | -119.5% | −24.3 |
| Q4 FY2023 | Dec 31, 2023 | -2.9% | +31.7 |
| Q3 FY2023 | Sep 30, 2023 | -102.2% | −72.8 |
| Q2 FY2023 | Jun 30, 2023 | -45.3% | +33.3 |
| Q1 FY2023 | Mar 31, 2023 | -95.2% | −49.3 |
| Q4 FY2022 | Dec 31, 2022 | -34.5% | −85.6 |
| Q3 FY2022 | Sep 30, 2022 | -29.4% | +32.5 |
| Q2 FY2022 | Jun 30, 2022 | -78.6% | −14.3 |
| Q1 FY2022 | Mar 31, 2022 | -45.9% | +34.6 |
| Q4 FY2021 | Dec 31, 2021 | 51.0% | +173.2 |
| Q3 FY2021 | Sep 30, 2021 | -62.0% | −46.7 |
| Q2 FY2021 | Jun 30, 2021 | -64.3% | −46.7 |
| Q1 FY2021 | Mar 31, 2021 | -80.5% | −50.8 |
| Q4 FY2020 | Dec 31, 2020 | -122.1% | −159.5 |
| Q3 FY2020 | Sep 30, 2020 | -15.3% | −30.9 |
| Q2 FY2020 | Jun 30, 2020 | -17.6% | −17.1 |
| Q1 FY2020 | Mar 31, 2020 | -29.7% | −58.1 |
| Q4 FY2019 | Dec 31, 2019 | 37.4% | −129.3 |
| Q3 FY2019 | Sep 30, 2019 | 15.6% | +18.7 |
| Q2 FY2019 | Jun 30, 2019 | -0.5% | +33.7 |
| Q1 FY2019 | Mar 31, 2019 | 28.4% | +29.4 |
| Q4 FY2018 | Dec 31, 2018 | 166.6% | +168.4 |
| Q3 FY2018 | Sep 30, 2018 | -3.1% | −0.9 |
| Q2 FY2018 | Jun 30, 2018 | -34.3% | −31.5 |
| Q1 FY2018 | Mar 31, 2018 | -1.0% | −8.7 |
| Q4 FY2017 | Dec 31, 2017 | -1.7% | −17.9 |
| Q3 FY2017 | Sep 30, 2017 | -2.2% | – |
| Q2 FY2017 | Jun 30, 2017 | -2.7% | – |
| Q1 FY2017 | Mar 31, 2017 | 7.7% | – |
| Q4 FY2016 | Dec 31, 2016 | 16.1% | – |
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