Ionis Pharmaceuticals Inc (IONS) stock
IONSNasdaqPharmaceutical PreparationsFiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 9, 2026Score 3/304% above fair value
$29.06+1.75 (+6.41%)
Close on Nov 13, 2026Market cap $4.83BP/E –Yield –
Ionis Pharmaceuticals operating margin
Operating margin is operating income as a percentage of revenue.
Ionis Pharmaceuticals's operating margin for the twelve months ending Sep 30, 2026 was -58.8%. For fiscal 2025 it was -40.4%, against -67.4% the year before. The highest annual figure on record is 32.6% in fiscal 2019.
Annual operating margin
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| FY2025 | Dec 31, 2025 | -40.4% | +26.9 |
| FY2024 | Dec 31, 2024 | -67.4% | −22.5 |
| FY2023 | Dec 31, 2023 | -44.9% | +24.9 |
| FY2022 | Dec 31, 2022 | -69.8% | −66.1 |
| FY2021 | Dec 31, 2021 | -3.7% | +19.9 |
| FY2020 | Dec 31, 2020 | -23.6% | −56.2 |
| FY2019 | Dec 31, 2019 | 32.6% | +42.8 |
| FY2018 | Dec 31, 2018 | -10.2% | −16.3 |
| FY2017 | Dec 31, 2017 | 6.0% | +11.4 |
| FY2016 | Dec 31, 2016 | -5.4% | +21.3 |
| FY2015 | Dec 31, 2015 | -26.7% | −4.4 |
| FY2014 | Dec 31, 2014 | -22.3% | +12.8 |
| FY2013 | Dec 31, 2013 | -35.1% | +32.5 |
| FY2012 | Dec 31, 2012 | -67.5% | +4.2 |
| FY2011 | Dec 31, 2011 | -71.8% | −27.2 |
| FY2010 | Dec 31, 2010 | -44.6% | −21.9 |
| FY2009 | Dec 31, 2009 | -22.6% | −10.5 |
| FY2008 | Dec 31, 2008 | -12.2% | – |
Quarterly operating margin
Change is against the same quarter a year earlier.
| Period | Period end | Value | Change (pts) |
|---|---|---|---|
| Q3 FY2026 | Sep 30, 2026 | -53.8% | +48.4 |
| Q2 FY2026 | Jun 30, 2026 | -38.2% | −69.1 |
| Q1 FY2026 | Mar 31, 2026 | -47.7% | +63.9 |
| Q4 FY2025 | Dec 31, 2025 | -105.5% | −56.6 |
| Q3 FY2025 | Sep 30, 2025 | -102.2% | +8.9 |
| Q2 FY2025 | Jun 30, 2025 | 30.9% | +60.3 |
| Q1 FY2025 | Mar 31, 2025 | -111.6% | +13.5 |
| Q4 FY2024 | Dec 31, 2024 | -48.9% | −47.0 |
| Q3 FY2024 | Sep 30, 2024 | -111.1% | −11.7 |
| Q2 FY2024 | Jun 30, 2024 | -29.3% | +18.5 |
| Q1 FY2024 | Mar 31, 2024 | -125.1% | −37.7 |
| Q4 FY2023 | Dec 31, 2023 | -1.9% | +135.1 |
| Q3 FY2023 | Sep 30, 2023 | -99.3% | −62.3 |
| Q2 FY2023 | Jun 30, 2023 | -47.9% | +16.0 |
| Q1 FY2023 | Mar 31, 2023 | -87.5% | −46.9 |
| Q4 FY2022 | Dec 31, 2022 | -137.0% | −187.1 |
| Q3 FY2022 | Sep 30, 2022 | -37.0% | +27.5 |
| Q2 FY2022 | Jun 30, 2022 | -63.9% | −5.9 |
| Q1 FY2022 | Mar 31, 2022 | -40.5% | +41.9 |
| Q4 FY2021 | Dec 31, 2021 | 50.1% | +57.9 |
| Q3 FY2021 | Sep 30, 2021 | -64.5% | −41.7 |
| Q2 FY2021 | Jun 30, 2021 | -58.0% | −22.5 |
| Q1 FY2021 | Mar 31, 2021 | -82.4% | −36.6 |
| Q4 FY2020 | Dec 31, 2020 | -7.8% | −60.6 |
| Q3 FY2020 | Sep 30, 2020 | -22.8% | −24.3 |
| Q2 FY2020 | Jun 30, 2020 | -35.6% | −24.1 |
| Q1 FY2020 | Mar 31, 2020 | -45.8% | −86.7 |
| Q4 FY2019 | Dec 31, 2019 | 52.8% | +47.2 |
| Q3 FY2019 | Sep 30, 2019 | 1.5% | +14.3 |
| Q2 FY2019 | Jun 30, 2019 | -11.5% | +31.2 |
| Q1 FY2019 | Mar 31, 2019 | 40.9% | +43.2 |
| Q4 FY2018 | Dec 31, 2018 | 5.6% | +9.3 |
| Q3 FY2018 | Sep 30, 2018 | -12.8% | −22.3 |
| Q2 FY2018 | Jun 30, 2018 | -42.7% | −48.4 |
| Q1 FY2018 | Mar 31, 2018 | -2.3% | −19.1 |
| Q4 FY2017 | Dec 31, 2017 | -3.7% | −29.4 |
| Q3 FY2017 | Sep 30, 2017 | 9.6% | – |
| Q2 FY2017 | Jun 30, 2017 | 5.7% | – |
| Q1 FY2017 | Mar 31, 2017 | 16.8% | – |
| Q4 FY2016 | Dec 31, 2016 | 25.7% | – |
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