ETONNasdaqPharmaceutical PreparationsFiscal year ends December 31
Eton Pharmaceuticals, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 13, 2026
$49.22−1.09 (-2.17%)
Close on Oct 19, 2026
- Market cap
- $1.61B
- P/E (TTM)
- 126.2
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
74.0%
21M of 29M shares
Institutional holders
165
55 new, 5 sold out
Net institutional buying
3M
In Q2 2026
Insider trades, 12 months
0 buys · 28 sales
Net sold $29.20M
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Opaleye Management, Inc. | 2,672,500 | 10.34% | 13G (passive) amendment | Sep 9, 2024 |
| EcoR1 Capital, LLC | 1,981,003 | 7.70% | 13G (passive) amendment | Dec 31, 2024 |
| BlackRock, Inc. | 1,882,410 | 6.90% | 13G (passive) amendment | Jun 30, 2026 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of ETON | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 2,860,000 | 10.01% | $103.53M | – | 9.38% |
| Nantahala Capital Management, LLC | 2,351,902 | 8.23% | $85.14M | +1,175,951 | 1.41% |
| EcoR1 Capital, LLC | 2,171,938 | 7.60% | $78.62M | – | 3.82% |
| BlackRock, Inc. | 1,895,833 | 6.63% | $68.63M | +178,547 | 0.00% |
| Vanguard Capital Management LLC | 976,570 | 3.42% | $35.35M | −17,519 | 0.00% |
| Morgan Stanley | 767,972 | 2.69% | $27.80M | +290,015 | 0.00% |
| State Street Corp | 701,786 | 2.46% | $25.40M | +171,571 | 0.00% |
| Geode Capital Management, LLC | 652,303 | 2.28% | $23.62M | +74,637 | 0.00% |
| Oberweis Asset Management Inc/ | 501,600 | 1.75% | $18.16M | +62,300 | 0.38% |
| National Philanthropic Trust | 492,112 | 1.72% | $17.81M | – | 0.26% |
| Westside Investment Management, Inc. | 431,160 | 1.51% | $15.61M | −36,755 | 2.05% |
| Pillsbury Lake Capital LLC | 387,157 | 1.35% | $14.02M | +22,203 | 3.83% |
| Nuveen, LLC | 375,707 | 1.31% | $13.60M | +317,757 | 0.00% |
| Bnp Paribas Arbitrage, Snc | 322,466 | 1.13% | $11.67M | +20,358 | 0.00% |
| Woodline Partners LP | 310,879 | 1.09% | $11.25M | +140,180 | 0.03% |
| Thompson Siegel & Walmsley LLC | 297,232 | 1.04% | $10.76K | −108,857 | 0.19% |
| Northern Trust Corp | 255,849 | 0.90% | $9.26M | +18,017 | 0.00% |
| Marshall Wace, Llp | 249,182 | 0.87% | $9.02M | +166,461 | 0.01% |
| Panoramic Capital, LLC | 208,192 | 0.73% | $7.54M | +23,192 | 3.24% |
| Vanguard Portfolio Management LLC | 194,591 | 0.68% | $7.04M | +42,843 | 0.00% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 165 | 21M | 74.0% | 55 / 58 | 36 / 5 | 5M | 1M |
| Q1 2026 | 116 | 18M | 62.2% | 30 / 36 | 32 / 17 | 3M | 1M |
| Q4 2025 | 104 | 16M | 57.4% | 21 / 28 | 37 / 19 | 1M | 3M |
| Q3 2025 | 103 | 19M | 64.9% | 27 / 26 | 28 / 11 | 3M | 1M |
| Q2 2025 | 87 | 17M | 59.7% | 26 / 35 | 19 / 25 | 5M | 2M |
| Q1 2025 | 86 | 15M | 51.1% | 26 / 29 | 22 / 11 | 3M | 2M |
| Q4 2024 | 71 | 14M | 47.7% | 27 / 27 | 11 / 3 | 4M | 1M |
| Q3 2024 | 48 | 10M | 35.0% | 13 / 10 | 9 / 9 | 2M | 1M |
| Q2 2024 | 45 | 10M | 34.5% | 7 / 6 | 16 / 6 | 3M | 0M |
| Q1 2024 | 44 | 8M | 26.9% | 2 / 13 | 13 / 13 | 1M | 0M |
| Q4 2023 | 56 | 8M | 26.8% | 14 / 19 | 9 / 8 | 1M | 1M |
| Q3 2023 | 50 | 7M | 24.1% | 22 / 10 | 5 / 5 | 1M | 1M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of ETON | Value | % of fund | As of |
|---|---|---|---|---|---|
| iShares Russell 2000 ETF | 694,013 | 2.43% | $25.12M | 0.03% | Jun 30, 2026 |
| Vanguard Total Stock Market Index Fund | 684,821 | 2.40% | $24.79M | 0.00% | Jun 30, 2026 |
| Oberweis Micro-Cap Fund | 483,900 | 1.69% | $17.52M | 1.08% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 291,898 | 1.02% | $13.55M | 0.04% | Jul 31, 2026 |
| Vanguard Extended Market Index Fund | 271,079 | 0.95% | $9.81M | 0.01% | Jun 30, 2026 |
| Nuveen Quant Small Cap Equity Fund | 253,380 | 0.89% | $11.76M | 0.29% | Jul 31, 2026 |
| Fidelity Small Cap Growth Fund | 252,960 | 0.88% | $11.74M | 0.13% | Jul 31, 2026 |
| iShares Russell 2000 Growth ETF | 246,453 | 0.86% | $8.92M | 0.06% | Jun 30, 2026 |
| State Street(R) SPDR(R) S&P(R) Pharmaceuticals ETF | 154,434 | 0.54% | $5.59M | 1.30% | Jun 30, 2026 |
| Fidelity Small Cap Growth K6 Fund | 131,980 | 0.46% | $6.13M | 0.13% | Jul 31, 2026 |
| Vanguard Russell 2000 Index Fund | 131,634 | 0.46% | $4.01M | 0.02% | May 31, 2026 |
| Fidelity Extended Market Index Fund | 119,450 | 0.42% | $3.64M | 0.01% | May 31, 2026 |
| Wasatch Micro Cap Fund | 91,924 | 0.32% | $3.33M | 0.49% | Jun 30, 2026 |
| iShares Micro-Cap ETF | 89,743 | 0.31% | $3.25M | 0.21% | Jun 30, 2026 |
| Fidelity SAI Small-Mid Cap Momentum Index Fund | 70,461 | 0.25% | $3.27M | 0.08% | Jul 31, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Sean Brynjelsen | President & CEO, Director | 1,029,849 | 3.60% | Aug 20, 2026 |
| David Krempa | Chief Business Officer | 37,025 | 0.13% | Aug 24, 2026 |
| Danka Radosavljevic | Chief Operating Officer | 22,473 | 0.08% | Aug 12, 2026 |
| Ipek Erdogan-Trinkaus | Chief Commercial Officer | 2,403 | 0.01% | Aug 4, 2026 |
| Judith M. Matthews | Chief Financial Officer | – | – | Aug 4, 2026 |
| James R. Gruber | Chief Financial Officer | 213,420 | 0.75% | Jan 14, 2026 |
| Paul V. Maier | Director | 73,358 | 0.26% | Aug 31, 2026 |
| Jennifer McKie Adams | Director | 0 | – | Aug 4, 2026 |
| Charles J. Casamento | Director | 68,420 | 0.24% | Aug 4, 2026 |
| Norbert G. Riedel | Director | 204,645 | 0.72% | Aug 4, 2026 |
| Management Inc. Opaleye | 10% owner | 2,705,000 | 9.46% | Jul 17, 2026 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Paul V. Maier Director | Aug 28, 2026 | Sale | −36,387 | $58.64 | $2.13M | 73,358 |
| Paul V. Maier Director | Aug 28, 2026 | Option exercise | +50,000 | $3.78 | $189.00K | 109,745 |
| Paul V. Maier Director | Aug 28, 2026 | Sale | −128 | $61.77 | $7.91K | 59,745 |
| Paul V. Maier Director | Aug 28, 2026 | Sale | −13,485 | $60.21 | $811.93K | 59,873 |
| Paul V. Maier Director | Aug 28, 2026 | Option exercise | +12,500 | $7.31 | $91.38K | 72,245 |
| Paul V. Maier Director | Aug 28, 2026 | Sale | −36,387 | $58.64 | $2.13M | 73,358 |
| Paul V. Maier Director | Aug 28, 2026 | Sale | −13,485 | $60.21 | $811.93K | 59,873 |
| Paul V. Maier Director | Aug 28, 2026 | Sale | −128 | $61.77 | $7.91K | 59,745 |
| Paul V. Maier Director | Aug 28, 2026 | Option exercise | +50,000 | $3.78 | $189.00K | 109,745 |
| David Krempa Chief Business Officer | Aug 24, 2026 | Sale | −25,000 | $65.07 | $1.63M | 37,025 |
| David Krempa Chief Business Officer | Aug 24, 2026 | Option exercise | +25,000 | $7.31 | $182.75K | 62,025 |
| Sean Brynjelsen President & CEO, Director | Aug 20, 2026 | Sale | −47,307 | $60.17 | $2.85M | 1,004,909 |
| Sean Brynjelsen President & CEO, Director | Aug 20, 2026 | Sale | −36,373 | $61.11 | $2.22M | 968,536 |
| Sean Brynjelsen President & CEO, Director | Aug 20, 2026 | Sale | −7,342 | $62.12 | $456.09K | 961,194 |
| Sean Brynjelsen President & CEO, Director | Aug 19, 2026 | Sale | −8,978 | $62.65 | $562.47K | 1,052,216 |
| Management Inc. Opaleye 10% owner | Jul 14, 2026 | Sale | −15,000 | $37.54 | $563.10K | 2,665,000 |
| Management Inc. Opaleye 10% owner | Jul 14, 2026 | Sale | −13,315 | $37.54 | $499.85K | 40,000 |
| Management Inc. Opaleye 10% owner | Jul 14, 2026 | Sale | −13,315 | $37.54 | $499.85K | 40,000 |
| Management Inc. Opaleye 10% owner | Jul 14, 2026 | Sale | −15,000 | $37.54 | $563.10K | 2,665,000 |
| Sean Brynjelsen President & CEO, Director | Jul 14, 2026 | Option exercise | +200,000 | $1.37 | $274.00K | 1,061,194 |
| Sean Brynjelsen President & CEO, Director | Jul 12, 2026 | Option exercise | +27,500 | – | – | 861,194 |
| David Krempa Chief Business Officer | Jul 12, 2026 | Option exercise | +10,000 | – | – | 37,025 |
| Management Inc. Opaleye 10% owner | Jul 7, 2026 | Sale | −6,685 | $38.37 | $256.50K | 53,315 |
| Management Inc. Opaleye 10% owner | Jul 7, 2026 | Sale | −20,000 | $38.37 | $767.40K | 2,680,000 |
| Management Inc. Opaleye 10% owner | Jul 6, 2026 | Sale | −10,000 | $38.00 | $380.00K | 2,700,000 |
| Management Inc. Opaleye 10% owner | Jul 2, 2026 | Sale | −65,000 | $37.39 | $2.43M | 2,710,000 |
| Management Inc. Opaleye 10% owner | Jul 2, 2026 | Sale | −25,000 | $37.39 | $934.75K | 60,000 |
| Jennifer McKie Adams Director | Jun 17, 2026 | Sale | −50,000 | $32.48 | $1.62M | 0 |
| Jennifer McKie Adams Director | Jun 17, 2026 | Option exercise | +50,000 | $3.78 | $189.00K | 50,000 |
| Sean Brynjelsen President & CEO, Director | May 28, 2026 | Sale | −119,852 | $31.88 | $3.82M | 833,842 |
| Sean Brynjelsen President & CEO, Director | May 28, 2026 | Sale | −148 | $32.67 | $4.84K | 833,694 |
| David Krempa Chief Business Officer | May 27, 2026 | Sale | −19,679 | $31.47 | $619.30K | 25,249 |
| David Krempa Chief Business Officer | May 27, 2026 | Option exercise | +7,203 | $3.58 | $25.79K | 44,928 |
| David Krempa Chief Business Officer | May 27, 2026 | Option exercise | +12,476 | $1.37 | $17.09K | 37,725 |
| David Krempa Chief Business Officer | May 26, 2026 | Sale | −37,524 | $31.49 | $1.18M | 25,249 |
| David Krempa Chief Business Officer | May 26, 2026 | Option exercise | +12,524 | $1.37 | $17.16K | 62,773 |
| David Krempa Chief Business Officer | May 26, 2026 | Option exercise | +25,000 | $1.38 | $34.50K | 50,249 |
| David Krempa Chief Business Officer | May 22, 2026 | Option exercise | +30,591 | $3.58 | $109.52K | 68,046 |
| David Krempa Chief Business Officer | May 22, 2026 | Sale | −32,963 | $33.22 | $1.10M | 35,083 |
| David Krempa Chief Business Officer | May 22, 2026 | Sale | −519 | $35.00 | $18.17K | 25,249 |
| David Krempa Chief Business Officer | May 22, 2026 | Sale | −9,315 | $33.88 | $315.59K | 25,768 |
| Norbert G. Riedel Director | Apr 21, 2026 | Option exercise | +12,500 | $7.31 | $91.38K | 47,500 |
| Norbert G. Riedel Director | Apr 21, 2026 | Option exercise | +19,655 | $8.61 | $169.23K | 67,155 |
| Norbert G. Riedel Director | Feb 3, 2026 | Option exercise | +30,000 | $4.42 | $132.60K | 35,000 |
| James R. Gruber Chief Financial Officer | Jan 14, 2026 | Tax withholding | −2,293 | $15.47 | $35.47K | 213,420 |
| David Krempa Chief Business Officer | Jan 14, 2026 | Tax withholding | −1,942 | $15.62 | $30.33K | 630,238 |
| Sean Brynjelsen President & CEO, Director, 10% owner | Jan 1, 2026 | Tax withholding | −5,015 | $15.39 | $77.18K | 2,889,266 |
| James R. Gruber Chief Financial Officer | Dec 12, 2025 | Tax withholding | −4,542 | $16.99 | $77.17K | 215,713 |
| Ipek Erdogan-Trinkaus Chief Commercial Officer | Dec 12, 2025 | Tax withholding | −85 | $16.90 | $1.44K | 2,403 |
| David Krempa Chief Business Officer | Dec 12, 2025 | Tax withholding | −6,264 | $17.00 | $106.49K | 632,180 |
| Sean Brynjelsen President & CEO, Director, 10% owner | Dec 12, 2025 | Tax withholding | −6,732 | $16.83 | $113.30K | 2,894,281 |
| James R. Gruber Chief Financial Officer | Aug 20, 2025 | Sale | −2,631 | $16.02 | $42.15K | 204,753 |
| James R. Gruber Chief Financial Officer | Aug 19, 2025 | Sale | −39,082 | $16.16 | $631.57K | 205,299 |
| David Krempa Chief Business Officer | Jun 16, 2025 | Sale | −10,223 | $14.73 | $150.58K | 612,646 |
| David Krempa Chief Business Officer | Jun 13, 2025 | Sale | −6,800 | $14.77 | $100.44K | 622,869 |
| David Krempa Chief Business Officer | Jun 12, 2025 | Sale | −16,977 | $14.92 | $253.30K | 629,669 |
| Management Inc. Opaleye 10% owner | Jun 10, 2025 | Buy | +5,000 | $15.82 | $79.10K | 2,770,000 |
| Management Inc. Opaleye 10% owner | Jun 10, 2025 | Buy | +2,930 | $15.82 | $46.35K | 85,000 |
| Sean Brynjelsen President & CEO, Director, 10% owner | Jun 5, 2025 | Sale | −70,000 | $16.81 | $1.18M | 2,873,513 |
| Sean Brynjelsen President & CEO, Director, 10% owner | Jun 4, 2025 | Sale | −70,000 | $17.00 | $1.19M | 2,943,513 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| David Krempa Officer | Oct 6, 2026 | 4,166 | $229.41K | Oct 6, 2026 | RSU Vest |
| Paul V. Maier Director | Aug 28, 2026 | 50,000 | $2.95M | Aug 28, 2026 | stock options |
| David Krempa Officer | Aug 24, 2026 | 25,000 | $1.63M | Aug 24, 2026 | Stock Option Exercise |
| Sean Brynjelsen Officer, Director | Aug 20, 2026 | 100,000 | $6.34M | Aug 19, 2026 | founder shares |
| Sean Brynjelsen Director, 10% Stockholder | Aug 19, 2026 | 100,000 | $6.34M | Aug 19, 2026 | Founder Shares |
| James R. Gruber Officer | Jun 26, 2026 | 251,818 | $8.99M | Jun 26, 2026 | Stock Option Exercies |
| James R. Gruber Officer | Jun 25, 2026 | 25,000 | $875.25K | Jun 25, 2026 | Stock Option Exercise |
| James R. Gruber Officer | Jun 23, 2026 | 25,000 | $830.87K | Jun 23, 2026 | Stock Option Exercise |
| Jennifer McKie Adams Director | Jun 17, 2026 | 50,000 | $1.62M | Jun 17, 2026 | Stock Options |
| James R. Gruber Officer | Jun 2, 2026 | 3,117 | $84.16K | Jun 2, 2026 | RSU |
| Sean Brynjelsen Director | May 28, 2026 | 120,000 | $3.89M | May 28, 2026 | Founder Shares |
| David Krempa Officer | May 22, 2026 | 100,000 | $3.50M | May 22, 2026 | RSU |
| David Krempa Officer | Jan 14, 2026 | 1,942 | $30.33K | Jan 14, 2026 | Grant |
| James R. Gruber Officer | Jan 14, 2026 | 2,293 | $35.48K | Jan 14, 2026 | Grant |
| Sean Brynjelsen Officer, Director, 10% Stockholder | Jan 14, 2026 | 5,015 | $77.18K | Jan 14, 2026 | GRANT |