DSGNNasdaqPharmaceutical PreparationsFiscal year ends December 31
Design Therapeutics, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 3, 2026
$10.64+0.33 (+3.20%)
Close on Oct 19, 2026
- Market cap
- $665.06M
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
69.2%
43M of 63M shares
Institutional holders
137
29 new, 16 sold out
Net institutional buying
5M
In Q2 2026
Insider trades, 12 months
0 buys · 0 sales
Open-market trades only
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Simeon George | 6,607,892 | 10.70% | 13D (active) amendment | Mar 9, 2026 |
| Alex Silverstein | 5,963,936 | 9.50% | 13G (passive) | Jun 30, 2026 |
| Light Irrevocable Trust #1 dated April 22, 2019 | 3,834,355 | 6.90% | 13G (passive) amendment | Dec 31, 2024 |
| Star Irrevocable Trust #1 dated April 22, 2019 | 3,834,355 | 6.90% | 13G (passive) amendment | Dec 31, 2024 |
| Point72 Capital Advisors, Inc. | 3,197,764 | 5.10% | 13G (passive) | Jun 8, 2026 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of DSGN | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Sr One Capital Management, LP | 6,526,476 | 10.43% | $94.44M | – | 9.09% |
| Logos Global Management LP | 3,000,000 | 4.79% | $43.41M | +1,050,000 | 1.87% |
| Baker Bros. Advisors LP | 2,678,430 | 4.28% | $38.76M | +92,452 | 0.19% |
| Driehaus Capital Management LLC | 2,661,115 | 4.25% | $38.51M | +916,128 | 0.22% |
| BlackRock, Inc. | 2,660,024 | 4.25% | $38.49M | +526,260 | 0.00% |
| Point72 Asset Management, L.P. | 2,366,453 | 3.78% | $34.24M | −356,301 | 0.04% |
| Trails Edge Capital Partners, LP | 2,001,282 | 3.20% | $28.96M | +1,149,269 | 4.60% |
| Frazier Life Sciences Management, L.P. | 1,809,854 | 2.89% | $26.19M | New | 0.57% |
| Vivo Capital, LLC | 1,612,903 | 2.58% | $23.34M | – | 2.13% |
| Vanguard Capital Management LLC | 1,571,022 | 2.51% | $22.73M | +221,172 | 0.00% |
| Caption Management, LLC | 1,118,098 | 1.79% | $16.18M | +1,031,390 | 0.08% |
| Almitas Capital LLC | 1,026,893 | 1.64% | $14.86M | −503,442 | 3.56% |
| Geode Capital Management, LLC | 958,417 | 1.53% | $13.87M | +265,899 | 0.00% |
| Sofinnova Investments, Inc. | 865,135 | 1.38% | $12.52M | New | 0.65% |
| FMR LLC | 776,462 | 1.24% | $11.24M | −21,949 | 0.00% |
| Morgan Stanley | 765,425 | 1.22% | $11.08M | +108,860 | 0.00% |
| State Street Corp | 736,221 | 1.18% | $10.65M | +76,646 | 0.00% |
| Woodline Partners LP | 700,354 | 1.12% | $10.13M | −261,147 | 0.03% |
| Dimensional Fund Advisors LP | 694,743 | 1.11% | $10.05M | +262,903 | 0.00% |
| Goldman Sachs Group Inc | 656,584 | 1.05% | $9.50M | +151,866 | 0.00% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 137 | 43M | 69.2% | 29 / 62 | 32 / 16 | 12M | 7M |
| Q1 2026 | 125 | 38M | 60.7% | 22 / 55 | 29 / 13 | 7M | 5M |
| Q4 2025 | 117 | 38M | 61.0% | 31 / 39 | 29 / 8 | 9M | 7M |
| Q3 2025 | 95 | 36M | 57.6% | 14 / 18 | 38 / 11 | 4M | 2M |
| Q2 2025 | 92 | 35M | 55.2% | 5 / 35 | 34 / 11 | 1M | 1M |
| Q1 2025 | 98 | 34M | 55.1% | 14 / 28 | 36 / 10 | 3M | 2M |
| Q4 2024 | 95 | 33M | 53.5% | 15 / 34 | 22 / 18 | 3M | 2M |
| Q3 2024 | 100 | 32M | 51.2% | 15 / 29 | 34 / 9 | 5M | 8M |
| Q2 2024 | 95 | 37M | 59.4% | 15 / 37 | 27 / 13 | 8M | 3M |
| Q1 2024 | 93 | 32M | 50.7% | 19 / 22 | 36 / 14 | 3M | 3M |
| Q4 2023 | 88 | 32M | 51.6% | 15 / 37 | 24 / 14 | 7M | 7M |
| Q3 2023 | 87 | 33M | 52.5% | 14 / 27 | 38 / 24 | 10M | 16M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of DSGN | Value | % of fund | As of |
|---|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,161,075 | 1.86% | $16.80M | 0.00% | Jun 30, 2026 |
| iShares Russell 2000 ETF | 816,383 | 1.30% | $11.81M | 0.01% | Jun 30, 2026 |
| Select Biotechnology Portfolio | 534,931 | 0.85% | $5.61M | 0.11% | May 31, 2026 |
| Vanguard Extended Market Index Fund | 373,877 | 0.60% | $5.41M | 0.01% | Jun 30, 2026 |
| Fidelity Small Cap Index Fund | 337,104 | 0.54% | $4.11M | 0.01% | Jul 31, 2026 |
| iShares Russell 2000 Growth ETF | 288,998 | 0.46% | $4.18M | 0.03% | Jun 30, 2026 |
| iShares Biotechnology ETF | 265,739 | 0.42% | $3.85M | 0.04% | Jun 30, 2026 |
| Fidelity Enhanced Small Cap Core ETF | 204,949 | 0.33% | $2.97M | 0.05% | Jun 30, 2026 |
| Dimensional U.S. Small Cap ETF | 156,210 | 0.25% | $1.90M | 0.01% | Jul 31, 2026 |
| Fidelity Extended Market Index Fund | 152,816 | 0.24% | $1.60M | 0.00% | May 31, 2026 |
| Schwab U.S. Small-Cap ETF | 144,577 | 0.23% | $1.52M | 0.01% | May 31, 2026 |
| North Square Dynamic Small Cap Fund | 143,991 | 0.23% | $1.51M | 0.19% | May 31, 2026 |
| U.S. Small Cap Portfolio | 135,805 | 0.22% | $1.65M | 0.01% | Jul 31, 2026 |
| Driehaus Micro Cap Growth Fund | 135,259 | 0.22% | $1.96M | 0.33% | Jun 30, 2026 |
| Invesco Dorsey Wright SmallCap Momentum ETF | 131,349 | 0.21% | $1.38M | 0.33% | May 31, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Pratik Shah | President, CEO and Chairperson, Director | 154,923 | 0.25% | Jan 5, 2026 |
| Julie Burgess | Chief Accounting Officer | – | – | Jan 5, 2026 |
| Chris Storgard | Chief Medical Officer | – | – | Jan 5, 2026 |
| Sean Jeffries | Chief Operating Officer | 810,283 | 1.29% | Jan 5, 2026 |
| Simeon George | Director, 10% owner | 6,526,476 | 10.43% | Jun 11, 2026 |
| John P. Schmid | Director | 57,639 | 0.09% | Jun 11, 2026 |
| David Shapiro | Director | – | – | Jun 11, 2026 |
| Rodney W. Lappe | Director | 133,024 | 0.21% | Jun 11, 2026 |
| Heather A. Berger | Director | 1,300 | 0.00% | Jun 11, 2026 |
| Justin D. Gover | Director | – | – | Jun 11, 2026 |
| Arsani William | Director | 3,655,000 | 5.84% | Aug 14, 2025 |
| Deepa Prasad | Director | 1,837,273 | 2.94% | Jun 12, 2025 |
| TRUST Co DUNHAM | 10% owner | – | – | Feb 7, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Arsani William Director | Aug 13, 2025 | Sale | −345,000 | $5.25 | $1.81M | 2,655,000 |
| Arsani William Director | Aug 13, 2025 | Sale | −217,627 | $5.25 | $1.14M | 1,000,000 |
| Deepa Prasad Director | Dec 18, 2024 | Sale | −3,806 | $6.27 | $23.86K | 20,000 |
| Arsani William Director | Aug 9, 2024 | Sale | −814,874 | $4.25 | $3.46M | 0 |
| Heather A. Berger Director | Mar 25, 2024 | Buy | +1,300 | $3.74 | $4.86K | 1,300 |
| John P. Schmid Director | Mar 25, 2024 | Buy | +17,809 | $3.74 | $66.61K | 26,965 |
| John P. Schmid Director | Mar 22, 2024 | Buy | +9,156 | $3.62 | $33.14K | 9,156 |
| Rodney W. Lappe Director | Sep 29, 2023 | Buy | +21,000 | $2.35 | $49.35K | 133,024 |
| Arsani William Director | Aug 29, 2023 | Buy | +1,960,000 | $2.44 | $4.78M | 3,000,000 |
| Deepa Prasad Director | Aug 29, 2023 | Buy | +12,000 | $2.31 | $27.72K | 23,806 |
| Arsani William Director | Aug 28, 2023 | Buy | +275,000 | $2.15 | $591.25K | 1,040,000 |
| Joao Siffert MD President and CEO, Director | Dec 20, 2022 | Buy | +6,300 | $8.38 | $52.79K | 132,619 |
| Sr One Capital Partners I, Lp 10% owner | Dec 20, 2022 | Buy | +40,000 | $8.14 | $325.60K | 6,526,476 |
| Simeon George Director, 10% owner | Dec 20, 2022 | Buy | +40,000 | $8.14 | $325.60K | 6,526,476 |
| Joao Siffert MD President and CEO, Director | Dec 19, 2022 | Buy | +1,150 | $8.47 | $9.74K | 126,319 |
| Sr One Capital Partners I, Lp 10% owner | Dec 19, 2022 | Buy | +360,000 | $8.63 | $3.11M | 6,486,476 |
| Simeon George Director, 10% owner | Dec 19, 2022 | Buy | +360,000 | $8.63 | $3.11M | 6,486,476 |
| Sr One Capital Partners I, Lp 10% owner | Dec 16, 2022 | Buy | +500,000 | $8.28 | $4.14M | 6,126,476 |
| Simeon George Director, 10% owner | Dec 16, 2022 | Buy | +500,000 | $8.28 | $4.14M | 6,126,476 |
| Rodney W. Lappe Director | Dec 9, 2022 | Buy | +15,000 | $7.96 | $119.40K | 112,024 |
| Stella Xu Director | Mar 22, 2022 | Sale | −1,455 | $18.63 | $27.11K | 4,129,950 |
| Arsani William Director | Mar 21, 2022 | Buy | +25,000 | $18.99 | $474.75K | 2,797,501 |
| Stella Xu Director | Mar 21, 2022 | Sale | −24,000 | $19.01 | $456.24K | 4,131,405 |
| Stella Xu Director | Mar 18, 2022 | Sale | −552,225 | $19.04 | $10.51M | 4,168,605 |
| Stella Xu Director | Mar 18, 2022 | Sale | −13,200 | $20.34 | $268.49K | 4,155,405 |
| Deepa Prasad Director | Mar 16, 2022 | Other | +11,806 | – | – | 11,806 |
| Arsani William Director | Aug 31, 2021 | Buy | +40,000 | $15.45 | $618.00K | 2,772,501 |
| Arsani William Director | Mar 30, 2021 | Buy | +700,000 | $20.00 | $14.00M | 700,000 |
| Arsani William Director | Mar 30, 2021 | Conversion | +814,874 | – | – | 814,874 |
| Arsani William Director | Mar 30, 2021 | Conversion | +1,217,627 | – | – | 1,217,627 |
| Cormorant Asset Management, LP – | Mar 30, 2021 | Conversion | +4,364,844 | – | – | 4,364,844 |
| Cormorant Asset Management, LP – | Mar 30, 2021 | Buy | +750,000 | $20.00 | $15.00M | 5,114,844 |
| Rodney W. Lappe Director | Mar 30, 2021 | Buy | +5,000 | $20.00 | $100.00K | 97,024 |
| Stella Xu Director, 10% owner | Mar 30, 2021 | Conversion | +280,991 | – | – | 4,720,830 |
| Stella Xu Director, 10% owner | Mar 30, 2021 | Buy | +10,000 | $20.00 | $200.00K | 4,730,830 |
| Stella Xu Director, 10% owner | Mar 30, 2021 | Conversion | +4,439,839 | – | – | 4,439,839 |
| Simeon George Director, 10% owner | Mar 30, 2021 | Conversion | +936,637 | – | – | 5,376,476 |
| Simeon George Director, 10% owner | Mar 30, 2021 | Buy | +250,000 | $20.00 | $5.00M | 5,626,476 |
| Simeon George Director, 10% owner | Mar 30, 2021 | Conversion | +4,439,839 | – | – | 4,439,839 |
| Pratik Shah Executive Chairperson, Director | Mar 30, 2021 | Buy | +25,000 | $20.00 | $500.00K | 25,000 |
| Pratik Shah Executive Chairperson, Director | Mar 30, 2021 | Conversion | +104,923 | – | – | 129,923 |
| Quan Venture Fund II, L.P. 10% owner | Mar 30, 2021 | Conversion | +280,991 | – | – | 4,720,830 |
| Quan Venture Fund II, L.P. 10% owner | Mar 30, 2021 | Conversion | +4,439,839 | – | – | 4,439,839 |
| Sean Jeffries Chief Operating Officer | Mar 30, 2021 | Buy | +3,050 | $20.00 | $61.00K | 3,050 |
| Arsani William Director | Mar 30, 2021 | Conversion | +814,874 | – | – | 2,032,501 |
| Arsani William Director | Mar 30, 2021 | Buy | +700,000 | $20.00 | $14.00M | 2,732,501 |
| Arsani William Director | Mar 30, 2021 | Conversion | +1,217,627 | – | – | 1,217,627 |
| Sr One Capital Management, Llc 10% owner | Mar 30, 2021 | Buy | +250,000 | $20.00 | $5.00M | 5,626,476 |
| Sr One Capital Management, Llc 10% owner | Mar 30, 2021 | Conversion | +4,439,839 | – | – | 4,439,839 |
| Sr One Capital Management, Llc 10% owner | Mar 30, 2021 | Conversion | +936,637 | – | – | 5,376,476 |
| Justin Thacker Vice President, Finance | Mar 30, 2021 | Buy | +17,500 | $20.00 | $350.00K | 17,500 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Global Master Fund LP Logos Director | Nov 18, 2025 | 120,000 | $891.60K | Nov 18, 2025 | open market |
| Global Master Fund LP Logos Director | Nov 14, 2025 | 620,000 | $4.38M | Nov 14, 2025 | open market |
| Global Master Fund LP Logos Director | Nov 7, 2025 | 415,000 | $2.85M | Nov 7, 2025 | Open market |
| Opportunities Fund II LP Logos Director | Aug 13, 2025 | 217,627 | $1.08M | Aug 13, 2025 | Private Market |
| Global Master Fund LP Logos Director | Aug 13, 2025 | 345,000 | $1.72M | Aug 13, 2025 | Public markets |
| SPV 1 LP Logos Director | Aug 9, 2024 | 814,874 | $3.46M | Aug 9, 2024 | Participation in Series B |