ANVSNYSEPharmaceutical PreparationsFiscal year ends December 31
Annovis Bio, Inc.
Financials through Q2 FY2026, quarter ended Jun 30, 2026Last filing: 10-Q on Aug 14, 2026
$0.96−0.03 (-3.36%)
Close on Oct 19, 2026
- Market cap
- $36.02M
- P/E (TTM)
- –
- Dividend yield
- –
Ownership
Institutional holdings as of Jun 30, 2026, from 13F filings
Held by institutions
25.5%
11M of 43M shares
Institutional holders
61
16 new, 11 sold out
Net institutional buying
6M
In Q2 2026
Insider trades, 12 months
19 buys · 0 sales
Net bought $4.46M
Shares held by institutions
Holders of more than 5%
Latest Schedule 13D (active) or 13G (passive) filed by each holder
| Holder | Shares | % of class | Filing | As of |
|---|---|---|---|---|
| Highbridge Capital Management, LLC | 2,775,578 | 6.10% | 13G (passive) | Jun 30, 2026 |
| Empery Asset Management, LP | 2,401,476 | 5.64% | 13G (passive) | Jun 30, 2026 |
Top institutional holders
13F holdings as of Jun 30, 2026
| Holder | Shares | % of ANVS | Value | Change | % of portfolio |
|---|---|---|---|---|---|
| Empery Asset Management, LP | 2,401,476 | 5.64% | $4.47M | New | 5.17% |
| Marshall Wace, Llp | 1,842,339 | 4.32% | $3.43M | +654,840 | 0.00% |
| Vanguard Capital Management LLC | 1,647,322 | 3.87% | $3.06M | +774,941 | 0.00% |
| Tudor Investment Corp Et Al | 1,357,134 | 3.19% | $2.52M | New | 0.00% |
| Renaissance Technologies LLC | 1,002,200 | 2.35% | $1.86M | +654,600 | 0.00% |
| Two Sigma Investments, LP | 579,571 | 1.36% | $1.08M | −48,088 | 0.00% |
| Geode Capital Management, LLC | 283,817 | 0.67% | $528.13K | +36,304 | 0.00% |
| BlackRock, Inc. | 249,856 | 0.59% | $464.73K | +110,323 | 0.00% |
| Citadel Advisors LLC | 243,682 | 0.57% | $453.25K | New | 0.00% |
| Vanguard Fiduciary Trust Co | 177,530 | 0.42% | $330.21K | +45,488 | 0.00% |
| Susquehanna International Group, Llp | 146,804 | 0.34% | $273.06K | −71,532 | 0.00% |
| Quadrature Capital Ltd | 90,884 | 0.21% | $169.04K | New | 0.00% |
| State Street Corp | 77,735 | 0.18% | $144.59K | – | 0.00% |
| Northern Trust Corp | 68,070 | 0.16% | $126.61K | −73,660 | 0.00% |
| First National Trust Co | 60,000 | 0.14% | $111.60K | +20,000 | 0.00% |
| Sherry Group, Inc. | 57,270 | 0.13% | $106.52K | – | 0.10% |
| Gsa Capital Partners Llp | 49,904 | 0.12% | $93 | +4,481 | 0.01% |
| Greenwich Wealth Management LLC | 48,400 | 0.11% | $90 | +1,400 | 0.00% |
| Headlands Technologies LLC | 48,071 | 0.11% | $89.41K | New | 0.01% |
| Wescott Financial Advisory Group, LLC | 41,607 | 0.10% | $77.39K | – | 0.01% |
Institutional buying and selling by quarter
Positions opened, added to, reduced and closed by 13F filers
| Quarter | Holders | Shares held | % of shares | New / added | Reduced / closed | Shares bought | Shares sold |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 61 | 11M | 25.5% | 16 / 18 | 6 / 11 | 7M | 0M |
| Q1 2026 | 56 | 5M | 11.1% | 14 / 13 | 10 / 9 | 2M | 1M |
| Q4 2025 | 53 | 4M | 9.9% | 20 / 17 | 3 / 8 | 3M | 0M |
| Q3 2025 | 42 | 2M | 4.8% | 5 / 11 | 8 / 5 | 0M | 0M |
| Q2 2025 | 42 | 2M | 4.3% | 10 / 12 | 6 / 12 | 0M | 1M |
| Q1 2025 | 44 | 2M | 4.9% | 13 / 16 | 4 / 8 | 1M | 0M |
| Q4 2024 | 40 | 2M | 3.7% | 9 / 13 | 9 / 4 | 1M | 0M |
| Q3 2024 | 35 | 1M | 2.8% | 12 / 11 | 4 / 7 | 0M | 0M |
| Q2 2024 | 31 | 1M | 2.3% | 6 / 8 | 8 / 6 | 0M | 0M |
| Q1 2024 | 31 | 1M | 2.9% | 6 / 12 | 6 / 10 | 0M | 0M |
| Q4 2023 | 36 | 1M | 2.8% | 11 / 10 | 7 / 5 | 0M | 0M |
| Q3 2023 | 30 | 1M | 2.6% | 3 / 6 | 9 / 1 | 0M | 0M |
Top mutual fund and ETF holders
Latest monthly portfolio reports (Form N-PORT)
| Fund | Shares | % of ANVS | Value | % of fund | As of |
|---|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,219,718 | 2.86% | $2.27M | 0.00% | Jun 30, 2026 |
| Vanguard Extended Market Index Fund | 393,887 | 0.92% | $732.63K | 0.00% | Jun 30, 2026 |
| Fidelity Extended Market Index Fund | 123,461 | 0.29% | $237.05K | 0.00% | May 31, 2026 |
| iShares Micro-Cap ETF | 103,332 | 0.24% | $192.20K | 0.01% | Jun 30, 2026 |
| Fidelity Total Market Index Fund | 34,459 | 0.08% | $66.16K | 0.00% | May 31, 2026 |
| Ultra-Small Company Market Fund | 33,577 | 0.08% | $62.45K | 0.04% | Jun 30, 2026 |
| Fidelity Series Total Market Index Fund | 33,419 | 0.08% | $64.16K | 0.00% | May 31, 2026 |
| Vanguard Balanced Index Fund | 20,994 | 0.05% | $39.05K | 0.00% | Jun 30, 2026 |
| Vanguard Institutional Total Stock Market Index Fund | 12,723 | 0.03% | $23.66K | 0.00% | Jun 30, 2026 |
| 1290 VT Micro Cap Portfolio | 6,991 | 0.02% | $13.00K | 0.01% | Jun 30, 2026 |
| Total Stock Market Index Trust | 557 | 0.00% | $1.04K | 0.00% | Jun 30, 2026 |
Officers, directors and major owners
People who filed Forms 3, 4 or 5 in the last two years
| Name | Role | Shares owned | % of shares | Latest filing |
|---|---|---|---|---|
| Maria-Luisa Maccecchini | President & CEO, Director | 1,212,020 | 2.84% | Nov 12, 2025 |
| Andrew Walsh | Vice President, Finance | 500 | 0.00% | Jun 18, 2025 |
| Michael B. Hoffman | Director | 3,533,307 | 8.29% | May 21, 2026 |
| Claudine Bruck | Director | 13,709 | 0.03% | Nov 12, 2025 |
| Reid McCarthy | Director | 9,305 | 0.02% | Jun 11, 2025 |
Insider trades
Common stock transactions reported on Form 4, newest first
| Insider | Date | Transaction | Shares | Price | Value | Shares after |
|---|---|---|---|---|---|---|
| Michael B. Hoffman Director | May 20, 2026 | Buy | +18,849 | $1.80 | $33.93K | 3,309,950 |
| Michael B. Hoffman Director | May 20, 2026 | Buy | +2,562 | $1.75 | $4.48K | 3,291,101 |
| Michael B. Hoffman Director | May 20, 2026 | Buy | +54,933 | $1.90 | $104.37K | 3,364,883 |
| Michael B. Hoffman Director | Apr 2, 2026 | Buy | +713,800 | $2.10 | $1.50M | 3,288,539 |
| Michael B. Hoffman Director | Dec 8, 2025 | Buy | +30,000 | $4.34 | $130.20K | 2,559,739 |
| Michael B. Hoffman Director | Dec 8, 2025 | Buy | +15,000 | $4.24 | $63.60K | 2,574,739 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +9,200 | $3.85 | $35.42K | 2,501,228 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +415 | $4.14 | $1.72K | 2,501,643 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +28,096 | $4.15 | $116.60K | 2,529,739 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +1,489 | $4.13 | $6.15K | 2,492,028 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +1,489 | $4.13 | $6.15K | 2,482,028 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +9,200 | $3.85 | $35.42K | 2,491,228 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +415 | $4.14 | $1.72K | 2,491,643 |
| Michael B. Hoffman Director | Nov 24, 2025 | Buy | +28,096 | $4.15 | $116.60K | 2,519,739 |
| Michael B. Hoffman Director | Nov 21, 2025 | Buy | +10,000 | $3.50 | $35.00K | 2,490,539 |
| Michael B. Hoffman Director | Nov 21, 2025 | Buy | +10,000 | $3.49 | $34.90K | 2,480,539 |
| Michael B. Hoffman Director | Nov 14, 2025 | Buy | +15,000 | $2.11 | $31.65K | 2,470,539 |
| Michael B. Hoffman Director | Oct 28, 2025 | Buy | +975,610 | $2.05 | $2.00M | 2,455,539 |
| Maria-Luisa Maccecchini President & CEO, Director | Oct 28, 2025 | Buy | +97,561 | $2.05 | $200.00K | 1,212,020 |
| Claudine Bruck Director | Sep 10, 2025 | Option exercise | +7,142 | $0.14 | $1,000 | 13,709 |
| Michael B. Hoffman Director | Aug 29, 2025 | Award | +5,000 | $2.28 | $11.40K | 1,469,929 |
| Michael B. Hoffman Director | Aug 29, 2025 | Award | +5,000 | $2.29 | $11.45K | 1,474,929 |
| Michael B. Hoffman Director | Aug 29, 2025 | Award | +5,000 | $2.30 | $11.50K | 1,479,929 |
| Michael B. Hoffman Director | Aug 19, 2025 | Award | +1,100 | $2.57 | $2.83K | 1,464,929 |
| Michael B. Hoffman Director | Aug 19, 2025 | Award | +6,717 | $2.60 | $17.46K | 1,453,001 |
| Michael B. Hoffman Director | Aug 19, 2025 | Award | +5,283 | $2.59 | $13.68K | 1,458,284 |
| Michael B. Hoffman Director | Aug 19, 2025 | Award | +5,545 | $2.58 | $14.31K | 1,463,829 |
| Andrew Walsh Vice President, Finance | Jun 16, 2025 | Award | +500 | $2.90 | $1.45K | 500 |
| Michael B. Hoffman Director | Jun 13, 2025 | Award | +25,000 | $2.80 | $70.00K | 1,446,283 |
| Michael B. Hoffman Director | Jun 13, 2025 | Award | +1 | $2.83 | $3 | 1,446,284 |
| Reid McCarthy Director | Jun 10, 2025 | Award | +2,000 | $2.95 | $5.90K | 9,305 |
| Maria-Luisa Maccecchini President & CEO, Director | Jun 4, 2025 | Award | +46,000 | $3.37 | $155.02K | 1,114,459 |
| Michael B. Hoffman Director | May 29, 2025 | Award | +5,000 | $2.43 | $12.15K | 1,421,283 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Mar 31, 2024 | Gift | −10,000 | – | – | 1,068,459 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Mar 31, 2024 | Gift | −10,000 | – | – | 1,078,459 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Mar 28, 2024 | Gift | −10,000 | – | – | 1,088,459 |
| Claudine Bruck Director | Nov 20, 2023 | Other | +0 | – | – | 6,567 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Nov 20, 2023 | Award | +40,970 | $6.10 | $249.92K | 1,098,459 |
| Michael B. Hoffman Director, 10% owner | Nov 20, 2023 | Award | +163,880 | $6.10 | $999.67K | 223,357 |
| Reid McCarthy Director | Nov 20, 2023 | Other | +0 | – | – | 7,305 |
| Henry Hagopian III Chief Financial Officer | Nov 20, 2023 | Award | +820 | $6.10 | $5.00K | 1,820 |
| Mark K. White Director | Nov 20, 2023 | Award | +1,990 | $6.10 | $12.14K | 61,167 |
| Mark K. White Director | Nov 20, 2023 | Award | +2,000 | $6.07 | $12.14K | 61,177 |
| Claudine Bruck Director | Nov 20, 2023 | Award | +1,000 | $6.07 | $6.07K | 7,567 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Nov 20, 2023 | Award | +41,186 | $6.07 | $250.00K | 1,098,675 |
| Reid McCarthy Director | Nov 20, 2023 | Award | +824 | $6.07 | $5.00K | 8,129 |
| Michael B. Hoffman Director, 10% owner | Nov 20, 2023 | Award | +164,745 | $6.07 | $1.00M | 224,222 |
| Henry Hagopian III Chief Financial Officer | Nov 20, 2023 | Award | +824 | $6.07 | $5.00K | 1,824 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Apr 24, 2023 | Gift | −3,000 | – | – | 1,057,489 |
| Mark K. White Director | Apr 7, 2023 | Award | +3,000 | $12.61 | $37.83K | 59,177 |
| Henry Hagopian III Chief Financial Officer | Apr 7, 2023 | Award | +1,000 | $12.61 | $12.61K | 1,000 |
| Michael B. Hoffman Director, 10% owner | Apr 7, 2023 | Award | +59,477 | $12.61 | $750.00K | 59,477 |
| Reid McCarthy Director | Apr 7, 2023 | Award | +476 | $12.61 | $6.00K | 7,305 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Apr 7, 2023 | Award | +20,000 | $12.61 | $252.20K | 1,060,489 |
| Claudine Bruck Director | Apr 7, 2023 | Award | +500 | $12.61 | $6.31K | 6,567 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Feb 6, 2023 | Option exercise | +52,755 | $0.14 | $7.39K | 1,040,489 |
| Maria-Luisa Maccecchini President and CEO, Director, 10% owner | Jan 14, 2022 | Option exercise | +32,959 | $0.14 | $4.61K | 987,734 |
| Michael B. Hoffman Director, 10% owner | Jan 4, 2022 | Option exercise | +30,000 | $4.39 | $131.70K | 1,415,889 |
| Michael B. Hoffman Director, 10% owner | Jan 4, 2022 | Tax withholding | −6,658 | $19.78 | $131.70K | 1,409,231 |
| Michael B. Hoffman Director, 10% owner | Jan 4, 2022 | Option exercise | +7,142 | $0.25 | $1.79K | 1,416,373 |
Awards, option exercises, tax withholding and gifts are shown alongside open-market buys and sales. Each name links to the filing on SEC EDGAR.
Planned insider sales
Notices of proposed sale filed on Form 144 before shares are sold
| Seller | Filed | Shares | Market value | Planned sale | Acquired through |
|---|---|---|---|---|---|
| Mark K. White Director | Apr 2, 2026 | 7,142 | $14.85K | Apr 2, 2026 | Option Exercise |