Madrigal Pharmaceuticals, Inc. (MDGL) stock analysis
Close on Nov 11, 2026Market cap $10.00BP/E –Yield –
StockData Score
Prices as of Nov 11, 2026How the score works
Weak5 of 30 checks passed
Madrigal Pharmaceuticals passes 5 of the 30 checks behind our score; 16 could not be run for lack of data and count as not passed. Each dot in the shape is one check — hover it for the numbers.
- Valuation
- 0/6
- Growth
- 1/6
- Past performance
- 2/6
- Financial health
- 2/6
- Dividend
- 0/6
What stands out
Low bankruptcy risk
The Altman Z-score is 6.78; above 3 is the safe zone and below 1.8 the distress zone.
Growing faster than the industry
Revenue grew 149% over the last twelve months; the Drugs median is 8.0%.
Return on equity above the industry
Madrigal Pharmaceuticals's return on equity of -53.3% is above the Drugs median of -58.9%.
Net margin above the industry
Madrigal Pharmaceuticals's net margin of -25.3% is above the Drugs median of -53.0%.
What to watch
Margin of safety under 20%
The price is 7.6% above fair value, so there is no margin of safety.
Trading above fair value
The share price of $433.03 is above our fair value estimate of $402.51.
Return on equity under 15%
Return on equity was -53.3% over the last twelve months and averaged -102% over five years; we look for 15% on both.
Return on capital under 10%
Return on invested capital was -1338%, below the 10% that usually covers the cost of capital.
Valuation0/6
P/E against its history
Not enough price and earnings history to compare.
P/E against the industry
Needs positive earnings and enough profitable companies in the industry.
EV/EBITDA against its history
Needs positive EBITDA and price history.
P/B above the industry
Madrigal Pharmaceuticals's price-to-book of 19.10 is above the Drugs median of 2.29.
Trading above fair value
The share price of $433.03 is above our fair value estimate of $402.51.
Margin of safety under 20%
The price is 7.6% above fair value, so there is no margin of safety.
Growth1/6
Revenue growth over 3 years
Needs three years of positive revenue.
EPS growth over 3 years
Needs positive EPS three years ago and today.
Earnings acceleration
Needs positive net income now, a year ago and five years ago.
Growing faster than the industry
Revenue grew 149% over the last twelve months; the Drugs median is 8.0%.
Company guidance
No outlook found in earnings releases from the last twelve months.
Gross margin trend
This company does not report gross profit.
Past performance2/6
Return on equity under 15%
Return on equity was -53.3% over the last twelve months and averaged -102% over five years; we look for 15% on both.
Return on capital under 10%
Return on invested capital was -1338%, below the 10% that usually covers the cost of capital.
Return on equity above the industry
Madrigal Pharmaceuticals's return on equity of -53.3% is above the Drugs median of -58.9%.
Earnings over 5 years
Needs positive net income five years ago and in the latest year.
Net margin against its history
Needs five years of revenue and net income.
Net margin above the industry
Madrigal Pharmaceuticals's net margin of -25.3% is above the Drugs median of -53.0%.
Financial health2/6
High debt
Debt is 65.1% of shareholders' equity, above the 40% we consider low.
Debt trend
Needs a balance sheet from five years ago with positive equity.
Debt not well covered by cash flow
Operating cash flow over the last twelve months equals -58.0% of total debt; we look for at least 20%.
Interest not well covered
Operating income covers interest expense -10.2 times; we look for at least 5.
Short-term assets cover short-term debts
Current assets are 3.20 times current liabilities.
Low bankruptcy risk
The Altman Z-score is 6.78; above 3 is the safe zone and below 1.8 the distress zone.
Dividend0/6
No dividend
Madrigal Pharmaceuticals has not paid a dividend in the last twelve months.
Yield against Treasuries
No dividend.
Yield against the market
No dividend.
Dividend stability
No dividend.
Earnings cover
No dividend.
Cash-flow cover
No dividend.
Fair value
How we estimate itOur estimate per share
$402.51
The share price is 8% above this estimate.
| Method | Multiple used | Own 5Y median | Industry median | Value per share | Weight |
|---|---|---|---|---|---|
| P/B | 7.8× | 13.6× | 2.3× | $176.68 | 50% |
| P/S | 11.3× | 18.1× | 4.8× | $628.35 | 50% |
| Fair value | $402.51 | 100% | |||
Valuation over time
Using the earnings and balance sheet published at each date, not today's.
- P/B at month end
- Own 5-year median 13.6
- Drugs median 2.3
An estimate from reported numbers and market multiples, not a price target or investment advice. It can be far off for companies whose profits are about to change sharply.
Market risk
From the past year of daily prices.
Liquidity
Low risk
- Average value traded per day
- $209.56M
- Value traded per 1% price move
- $97.31M
Downside
Medium risk
- Typical loss in a bad month
- 17.7%
- Volatility (annualized)
- 44%
- Sharpe ratio, 1 year
- -0.39
- Beta to the S&P 500 (5Y)
- 0.73
Typical bad-month loss, week by week
Margins
Share of revenue, fiscal years 2011 to 2025
Operating margin
Net margin
Growth rates
Compound annual growth to fiscal 2025
| Per year | 1 year | 3 years | 5 years | 10 years | Five-year pace |
|---|---|---|---|---|---|
| Revenue | +432.1% | – | – | – |
Returns and balance sheet
10 fiscal years. Hover a measure to see how it is calculated.
| Measure | FY2016 | FY2020 | FY2025 | Trend |
|---|---|---|---|---|
| Return on equity | 422.1% | -61.6% | -42.5% | |
| Return on assets | -126.9% | -55.5% | -25.0% | |
| Current ratio | 8.58 | 6.13 | 4.01 | |
| Debt to equity | – | – | 0.56 | |
| Net debt to EBITDA | – | – | -0.47× | |
| Interest coverage | -20.8× | – | -13.5× | |
| Capex to revenue | – | – | 0.0% | |
| Diluted shares | 5M | 15M | 28M |
Where the cash went
Fiscal 2021 to 2025, five years combined
Madrigal Pharmaceuticals generated $1.38B from operations and spent $3.83M on capital expenditure, dividends and share buybacks. 100% of that went back into the business.
DuPont analysis
Return on equity split into margin, efficiency and leverage
| Fiscal year | Net margin | Asset turnover | Equity multiplier | Return on equity |
|---|---|---|---|---|
| FY2025 | -30.1% | 0.83× | 1.70× | -42.5% |
| FY2024 | -258.6% | 0.21× | 1.45× | -80.3% |
Piotroski F-Score
Nine tests of profitability, balance sheet and efficiency, fiscal 2025 against fiscal 2024
- ProfitableNet income above zero-$288.28M
- Cash generatingOperating cash flow above zero-$189.55M
- Return on assets improvedROA up on the prior year-72.7% → -27.7%
- Earnings backed by cashOperating cash flow above net income-$189.55M vs -$288.28M
- Less leverageLong-term debt to assets fell11.3% → 27.0%
- Better liquidityCurrent ratio rose6.10 → 4.01
- No dilutionShare count did not rise27M → 28M
- Gross margin improvedGross margin up on the prior year96.54% → –
- More efficientAsset turnover rose0.28 → 0.92
See a number that looks wrong?