Upstream Bio, Inc. (UPB) stock
Close on Nov 13, 2026Market cap $152.26MP/E –Yield –
Upstream Bio statistics
67 measures from SEC filings and the closing price. Hover a name for the formula; the last column is the median of companies in the same industry group.
Important dates
- Next earnings
- Mar 25, 2027 (estimated, before the open)
- Last ex-dividend date
- No dividends
- Fundamentals through
- Sep 30, 2026
- Share price as of
- Nov 13, 2026
Valuation ratiosIndustry
- P/TBV Ratio
- 0.65
- 2.22
Enterprise valuationIndustry
- EV / Sales
- -19.20
- 2.57
Share statisticsIndustry
- Shares Change (QoQ)
- 0.07%
- 0.50%
- Float
- 50M
- 49M
- Shares Held by Insiders
- 8.62%
- 11.7%
- Shares Held by Institutions
- 92.3%
- 56.4%
Short sellingIndustry
- Short Interest
- 4M
- –
- Short Interest Change
- -20.8%
- -0.80%
- Short % of Float
- 7.09%
- 9.01%
- Short % of Shares Outstanding
- 6.48%
- 6.30%
- Days to Cover
- 2.70
- 5.15
Stock price statisticsIndustry
- 52-Week High
- $33.68
- –
- 52-Week Low
- $2.68
- –
- 20-Day Moving Average
- $3.10
- –
- 50-Day Moving Average
- $4.24
- –
- 200-Day Moving Average
- $7.89
- –
- Average True Range (14)
- $0.35
- –
- Price Change (1 Week)
- -13.9%
- -1.15%
- Price Change (1 Month)
- -17.5%
- -4.87%
- Price Change (3 Months)
- -61.1%
- -21.0%
- Price Change (6 Months)
- -69.4%
- -20.6%
- Price Change (YTD)
- -89.8%
- -23.6%
- Price Change (1 Year)
- -88.3%
- -22.4%
- Average Volume (10 Days)
- 1M
- –
- Average Volume (20 Days)
- 1M
- –
- Average Volume (90 Days)
- 836,425
- –
- Relative Volume
- 1.07
- 0.70
- Relative Strength Index (14)
- 35.2
- 43.4
- Volatility (1 Year)
- 92.9%
- 80.1%
- Beta (5 Years)
- 1.28
- 1.07
MarginsIndustry
- EBITDA Margin
- -6108.9%
- -27.7%
Returns on capitalIndustry
- Return on Equity (ROE)
- -53.5%
- -49.9%
- Return on Assets (ROA)
- -51.5%
- -40.6%
- Return on Invested Capital (ROIC)
- -846.4%
- -32.9%
- Return on Capital Employed (ROCE)
- -75.0%
- -37.9%
Financial positionIndustry
- Current Ratio
- 20.45
- 3.30
- Quick Ratio
- 17.37
- 2.39
GrowthIndustry
- Revenue Growth (YoY)
- 2.54%
- 6.82%
EfficiencyIndustry
- Asset Turnover
- 0.01
- 0.40
- Revenue Per Employee
- $38.27K
- $429.29K
- Profits Per Employee
- -$2.19M
- -$689.41K
- Employee Count
- 75
- 74
- WACC
- 11.5%
- 10.2%
Income statement (TTM)Industry
Balance sheetIndustry
- Net Cash (Debt)
- $207.37M
- $17.76M
- Net Cash Per Share
- $3.79
- $0.80
- Equity (Book Value)
- $233.98M
- $53.89M
- Book Value Per Share
- $4.27
- $1.50
- Tangible Book Value
- $233.98M
- $27.13M
- Working Capital
- $232.67M
- $79.99M
Cash flow (TTM)Industry
Dividends and yieldsIndustry
- Earnings Yield
- -107.7%
- -21.8%
Taxes and interestIndustry
- Income Tax
- $0
- $73.00K
Scores and fair valueIndustry
- Altman Z-Score
- 3.80
- 0.23
- Piotroski F-Score
- 1
- 4
Total return vs. the S&P 500
Price change plus reinvested dividends, to the close on Nov 13, 2026. The S&P 500 is measured by the SPY fund.
| Period | UPB | S&P 500 | Difference | UPB per year | S&P 500 per year |
|---|---|---|---|---|---|
| 1 month | -21.7% | -3.0% | −18.7 pts | ||
| 3 months | -59.8% | -2.8% | −57.0 pts | ||
| Year to date | -89.8% | +11.5% | −101.2 pts | ||
| 1 year | -88.1% | +13.5% | −101.6 pts |
Short interest
Shares sold short and not yet covered, reported by brokers to FINRA twice a month. Latest settlement date Oct 30, 2026.
4M UPB shares were sold short on Oct 30, 2026, down 20.8% from the previous report, or 7.09% of the shares available to trade. At recent volumes it would take 2.7 days to buy them back. Over the last 20 sessions, 18.2% of the volume reported to FINRA was short selling.
| Settlement date | Shares short | Change | Avg. daily volume | Days to cover |
|---|---|---|---|---|
| Oct 30, 2026 | 3,550,200 | -20.8% | 1,316,186 | 2.7 |
| Oct 15, 2026 | 4,480,785 | -0.8% | 1,215,658 | 3.7 |
| Sep 30, 2026 | 4,514,865 | +0.5% | 587,966 | 7.7 |
| Sep 15, 2026 | 4,490,724 | +9.7% | 656,192 | 6.8 |
| Aug 31, 2026 | 4,095,011 | +2.0% | 549,503 | 7.5 |
| Aug 14, 2026 | 4,016,614 | +10.1% | 712,393 | 5.6 |
| Jul 31, 2026 | 3,648,558 | +0.8% | 486,961 | 7.5 |
| Jul 15, 2026 | 3,618,151 | -11.9% | 442,098 | 8.2 |
| Jun 30, 2026 | 4,105,630 | +5.3% | 718,338 | 5.7 |
| Jun 15, 2026 | 3,898,229 | +7.1% | 711,476 | 5.5 |
| May 29, 2026 | 3,640,867 | +7.2% | 534,404 | 6.8 |
| May 15, 2026 | 3,397,759 | +5.4% | 507,812 | 6.7 |
Ratios use trailing-twelve-month results and the latest balance sheet. How we calculate.
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