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Prime Medicine, Inc. (PRME) stock

PRMENasdaqBiological Products, (No Diagnostic Substances)Fiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 12, 2026Score 5/30
$4.27+0.38 (+9.77%)

Close on Nov 13, 2026Market cap $774.48MP/E –Yield –

Prime Medicine statistics

64 measures from SEC filings and the closing price. Hover a name for the formula; the last column is the median of companies in the same industry group.

Important dates

Next earnings
Mar 2, 2027 (estimated, before the open)
Last ex-dividend date
No dividends
Fundamentals through
Sep 30, 2026
Share price as of
Nov 13, 2026

Valuation ratiosIndustry

Market Cap
$774.48M
$272.32M
Enterprise Value
$713.28M
$146.23M
PB Ratio
91.80
2.00
P/TBV Ratio
91.80
2.22

Share statisticsIndustry

Shares Change (YoY)
28.6%
10.8%
Shares Change (QoQ)
0.36%
0.50%
Float
148M
49M
Shares Held by Insiders
18.6%
11.7%
Shares Held by Institutions
58.8%
56.4%

Short sellingIndustry

Short Interest
29M
–
Short Interest Change
-11.3%
-0.80%
Short % of Float
19.7%
9.01%
Short % of Shares Outstanding
16.1%
6.30%
Days to Cover
4.80
5.15

Stock price statisticsIndustry

52-Week High
$5.91
–
52-Week Low
$2.67
–
20-Day Moving Average
$4.30
–
50-Day Moving Average
$3.70
–
200-Day Moving Average
$3.50
–
Average True Range (14)
$0.49
–
Price Change (1 Week)
-8.17%
-1.15%
Price Change (1 Month)
18.3%
-4.87%
Price Change (3 Months)
34.7%
-21.0%
Price Change (6 Months)
45.7%
-20.6%
Price Change (YTD)
23.1%
-23.6%
Price Change (1 Year)
20.3%
-22.4%
Price Change (3 Years)
-39.6%
-29.5%
Price Change (10 Years)
-77.6%
-65.4%
Average Volume (10 Days)
5M
–
Average Volume (20 Days)
6M
–
Average Volume (90 Days)
4M
–
Relative Volume
1.48
0.70
Relative Strength Index (14)
51.9
43.4
Volatility (1 Year)
92.6%
80.1%
Beta (5 Years)
2.05
1.07

Returns on capitalIndustry

Return on Equity (ROE)
-207.2%
-49.9%
Return on Assets (ROA)
-58.9%
-40.6%
Return on Capital Employed (ROCE)
-102.4%
-37.9%

Financial positionIndustry

Current Ratio
1.79
3.30
Quick Ratio
1.72
2.39

GrowthIndustry

Revenue Growth (5Y CAGR)
-2.32%
6.41%

EfficiencyIndustry

Profits Per Employee
-$1.21M
-$689.41K
Employee Count
146
74
WACC
15.4%
10.2%

Income statement (TTM)Industry

Operating Income
-$182.47M
-$21.37M
Net Income
-$176.35M
-$22.35M
EBITDA
-$175.20M
-$17.21M
EPS (Diluted)
-$1.00
-$0.76

Balance sheetIndustry

Net Cash (Debt)
$61.20M
$17.76M
Net Cash Per Share
$0.34
$0.80
Equity (Book Value)
$8.44M
$53.89M
Book Value Per Share
$0.05
$1.50
Tangible Book Value
$8.44M
$27.13M
Working Capital
$28.06M
$79.99M

Cash flow (TTM)Industry

Operating Cash Flow
-$157.70M
-$12.38M
Capital Expenditures
-$848.00K
-$1.00M
Free Cash Flow
-$158.54M
-$18.21M
FCF Per Share
-$0.87
-$0.42

Dividends and yieldsIndustry

Earnings Yield
-22.8%
-21.8%
FCF Yield
-20.5%
-9.44%

Scores and fair valueIndustry

Altman Z-Score
-7.06
0.23
Piotroski F-Score
4
4

Total return vs. the S&P 500

Price change plus reinvested dividends, to the close on Nov 13, 2026. The S&P 500 is measured by the SPY fund.

PeriodPRMES&P 500DifferencePRME per yearS&P 500 per year
1 month+28.6%-3.0%+31.7 pts
3 months+34.7%-2.8%+37.5 pts
Year to date+23.1%+11.5%+11.6 pts
1 year+28.2%+13.5%+14.8 pts
3 years-35.9%+77.7%−113.6 pts-13.8%+21.1%
5 years-78.9%+72.6%−151.5 pts-26.7%+11.5%
10 years-77.9%+308.2%−386.1 pts-14.0%+15.1%

Short interest

Shares sold short and not yet covered, reported by brokers to FINRA twice a month. Latest settlement date Oct 30, 2026.

29M PRME shares were sold short on Oct 30, 2026, down 11.3% from the previous report, or 19.74% of the shares available to trade. At recent volumes it would take 4.8 days to buy them back. Over the last 20 sessions, 47.2% of the volume reported to FINRA was short selling.

Settlement dateShares shortChangeAvg. daily volumeDays to cover
Oct 30, 202629,147,049-11.3%6,070,7674.8
Oct 15, 202632,871,532+2.4%5,957,2045.5
Sep 30, 202632,116,376-0.0%3,802,9418.4
Sep 15, 202632,132,218-12.6%2,610,87012.3
Aug 31, 202636,761,940+5.0%2,798,97013.1
Aug 14, 202635,022,290+0.1%2,533,30713.8
Jul 31, 202635,003,578+4.4%2,714,29412.9
Jul 15, 202633,536,516-3.4%4,978,5086.7
Jun 30, 202634,729,797+6.7%3,810,7519.1
Jun 15, 202632,533,956+5.6%2,883,76711.3
May 29, 202630,820,036+1.0%2,749,34511.2
May 15, 202630,528,072+0.6%2,601,56611.7

Ratios use trailing-twelve-month results and the latest balance sheet. How we calculate.

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