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Orchestra BioMed Holdings, Inc. (OBIO) stock

OBIONasdaqSurgical & Medical Instruments & ApparatusFiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 10, 2026Score 9/30
$6.15+0.14 (+2.33%)

Close on Nov 12, 2026Market cap $369.65MP/E –Yield –

Orchestra BioMed Holdings, Inc. grew revenue 1007.4% to $31.21M over the twelve months to Sep 30, 2026. Free cash flow was -$64.18M. At the latest close the market valued the company at $369.65M.

Revenue
$31.21M
+1007.4% vs. a year earlier
Operating income
-$60.97M
TTM Q3 2026
Free cash flow
-$64.18M
TTM Q3 2026
EPS, diluted
-$0.91
TTM Q3 2026

Key statistics

Valuation at the latest close; fundamentals over the trailing twelve months, balances at Sep 30, 2026

Valuation

Market cap
$369.65M
P/E ratio
–
Price to sales
11.85
Price to book
–
Dividend yield
–
Free cash flow yield
-17.36%

Fundamentals

Revenue
$31.21M
Net income
-$56.95M
EPS, diluted
-$0.91
Free cash flow
-$64.18M
Diluted shares
65M

Trading

Previous close
$6.01
Open
$5.99
Day's range
$5.70 – $6.18
Volume
631,083
Average volume (20 days)
483,382
Index membership
Russell 2000 (since Jun 2026)
Beta (5 years)
0.80
52-week range
$3.46 – $6.50
RSI (14 days)
55.6
Volatility (1 year)
64.1%
Relative volume
1.37×
WACC
8.9%

On 2 of our idea lists: Insider cluster buys, Institutions accumulating

Index membership is inferred from the holdings of funds that track each index (IWM), as reported to the SEC for Jun 30, 2026. Join dates come from quarterly fund reports since 2019, so they are accurate to the quarter.

Market cap history

Month-end market cap since 2021, using shares outstanding reported at the time

Total return vs. the S&P 500

Price change plus reinvested dividends, to the close on Nov 12, 2026. The S&P 500 is measured by the SPY fund.

PeriodOBIOS&P 500DifferenceOBIO per yearS&P 500 per year
1 month+4.1%-2.7%+6.8 pts
3 months+39.1%-1.7%+40.9 pts
Year to date+48.2%+11.9%+36.3 pts
1 year+39.1%+12.0%+27.2 pts
3 years+16.7%+78.2%−61.5 pts+5.3%+21.2%
5 years-37.6%+73.2%−110.9 pts-9.0%+11.6%

Six years at a glance

Fiscal years 2020 to 2025 and trailing twelve months, USD

Revenue

$31.21M+1007.4% YoY

Gross profit

$31.07M+1085.4% YoY

Operating income

-$60.97M

Net income

-$56.95M

EPS, diluted

-$0.91

Free cash flow

-$64.18M
Reported periodTrailing twelve months

Press releases

Releases Orchestra BioMed filed with the SEC as exhibits to Form 8-K or 6-K

All press releases and earnings

About Orchestra BioMed

Surgical & Medical Instruments & Apparatus

Orchestra BioMed Holdings, Inc. is a biomedical innovation company focused on developing therapeutic medical technologies through risk-and-reward sharing partnerships with major global medical device companies. The company operates across two principal product development platforms: bioelectronic therapies and interventional devices. Its flagship bioelectronic candidate, Atrioventricular Interval Modulation (AVIM) Therapy, is an algorithmic, firmware-integrated treatment for uncontrolled hypertension in cardiac pacemaker patients, being co-developed under an exclusive global license and collaboration with Medtronic. Its lead interventional candidate, the Virtue Sirolimus AngioInfusion Balloon (Virtue SAB), is a drug-device combination delivering an extended-release sirolimus formulation for treating atherosclerotic artery disease, specifically targeting coronary in-stent restenosis and related vascular conditions.

Company profile, executives and history

Orchestra BioMed stock: common questions

What is Orchestra BioMed's stock price?

OBIO closed at $6.15 on Nov 12, 2026, up 2.33% on the day. Over the past 52 weeks it traded between $3.46 and $6.50.

What is Orchestra BioMed's market cap?

Orchestra BioMed was worth $369.65M at the close on Nov 12, 2026: the share price times the diluted shares outstanding.

What is OBIO's P/E ratio?

Orchestra BioMed lost money over the twelve months to Sep 30, 2026 (diluted EPS -$0.91), so it has no meaningful P/E ratio.

How much revenue does Orchestra BioMed make?

Orchestra BioMed reported revenue of $31.21M for the twelve months to Sep 30, 2026, up 1007.4% from a year earlier.

Does Orchestra BioMed pay a dividend?

No. Orchestra BioMed has not paid a cash dividend over the last twelve months.

How has OBIO stock performed over the past year?

Including dividends, OBIO returned +39.1% over the past year, against +12.0% for the S&P 500.

How many OBIO shares are sold short?

3M shares were sold short at the latest FINRA report, 10.48% of the float, or 7.0 days of average trading volume.

Who are Orchestra BioMed's competitors?

Companies most similar to Orchestra BioMed by business, industry and size include CVRX, CLPT, BWAY, BDMD, PLSM.

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