Ionis Pharmaceuticals Inc (IONS) stock
IONSNasdaqPharmaceutical PreparationsFiscal year ends December 31
Financials through Q3 FY2026, quarter ended Sep 30, 2026Last filing: 10-Q on Nov 9, 2026Score 3/304% above fair value
$29.06+1.75 (+6.41%)
Close on Nov 13, 2026Market cap $4.83BP/E –Yield –
Ionis Pharmaceuticals statistics
84 measures from SEC filings and the closing price. Hover a name for the formula; the last column is the median of companies in the same industry group.
Important dates
- Next earnings
- Feb 24, 2027 (estimated, before the open)
- Last ex-dividend date
- No dividends
- Fundamentals through
- Sep 30, 2026
- Share price as of
- Nov 13, 2026
Valuation ratiosIndustry
- P/TBV Ratio
- 12.27
- 2.22
Enterprise valuationIndustry
- EV / Sales
- 3.07
- 2.57
Share statisticsIndustry
- Shares Change (YoY)
- 0.02%
- 10.8%
- Shares Change (QoQ)
- 0.47%
- 0.50%
- Float
- 165M
- 49M
- Shares Held by Insiders
- 0.80%
- 11.7%
- Shares Held by Institutions
- 108.2%
- 56.4%
Short sellingIndustry
- Short Interest
- 21M
- –
- Short Interest Change
- 2.48%
- -0.80%
- Short % of Float
- 12.8%
- 9.01%
- Short % of Shares Outstanding
- 12.7%
- 6.30%
- Days to Cover
- 8.41
- 5.15
Stock price statisticsIndustry
- 52-Week High
- $86.74
- –
- 52-Week Low
- $27.25
- –
- 20-Day Moving Average
- $39.25
- –
- 50-Day Moving Average
- $43.66
- –
- 200-Day Moving Average
- $64.50
- –
- Average True Range (14)
- $2.34
- –
- Price Change (1 Week)
- -26.3%
- -1.15%
- Price Change (1 Month)
- -34.1%
- -4.87%
- Price Change (3 Months)
- -50.4%
- -21.0%
- Price Change (6 Months)
- -60.9%
- -20.6%
- Price Change (YTD)
- -63.3%
- -23.6%
- Price Change (1 Year)
- -60.0%
- -22.4%
- Price Change (3 Years)
- -40.9%
- -29.5%
- Price Change (5 Years)
- -11.1%
- -77.9%
- Price Change (10 Years)
- -38.8%
- -65.4%
- Average Volume (10 Days)
- 7M
- –
- Average Volume (20 Days)
- 5M
- –
- Average Volume (90 Days)
- 4M
- –
- Relative Volume
- 1.54
- 0.70
- Relative Strength Index (14)
- 24.2
- 43.4
- Volatility (1 Year)
- 48.7%
- 80.1%
- Beta (5 Years)
- 0.68
- 1.07
MarginsIndustry
- Pretax Margin
- -56.6%
- -11.6%
- EBITDA Margin
- -58.8%
- -27.7%
- FCF Margin
- -64.2%
- -9.56%
Returns on capitalIndustry
- Return on Equity (ROE)
- -108.1%
- -49.9%
- Return on Assets (ROA)
- -18.4%
- -40.6%
- Return on Capital Employed (ROCE)
- -22.8%
- -37.9%
Financial positionIndustry
- Current Ratio
- 5.43
- 3.30
- Quick Ratio
- 4.33
- 2.39
- Interest Coverage
- -29.37
- -6.35
GrowthIndustry
- Revenue Growth (YoY)
- -0.71%
- 6.82%
- Revenue Growth (3Y CAGR)
- 17.1%
- 2.25%
- Revenue Growth (5Y CAGR)
- 5.29%
- 6.41%
EfficiencyIndustry
- Asset Turnover
- 0.32
- 0.40
- Inventory Turnover
- 0.87
- 2.73
- Revenue Per Employee
- $684.80K
- $429.29K
- Profits Per Employee
- -$389.83K
- -$689.41K
- Employee Count
- 1,402
- 74
- WACC
- 8.48%
- 10.2%
Income statement (TTM)Industry
- Pretax Income
- -$543.72M
- -$12.95M
Balance sheetIndustry
- Net Cash (Debt)
- $1.88B
- $17.76M
- Net Cash Per Share
- $11.34
- $0.80
- Equity (Book Value)
- $393.64M
- $53.89M
- Book Value Per Share
- $2.37
- $1.50
- Tangible Book Value
- $393.64M
- $27.13M
- Working Capital
- $1.93B
- $79.99M
Cash flow (TTM)Industry
- Capital Expenditures
- -$71.85M
- -$1.00M
- FCF Per Share
- -$3.71
- -$0.42
Dividends and yieldsIndustry
- Earnings Yield
- -11.3%
- -21.8%
- FCF Yield
- -12.8%
- -9.44%
Taxes and interestIndustry
- Interest Expense
- $19.23M
- $2.90M
- Income Tax
- $2.82M
- $73.00K
Scores and fair valueIndustry
- Altman Z-Score
- 0.22
- 0.23
- Piotroski F-Score
- 4
- 4
Total return vs. the S&P 500
Price change plus reinvested dividends, to the close on Nov 13, 2026. The S&P 500 is measured by the SPY fund.
| Period | IONS | S&P 500 | Difference | IONS per year | S&P 500 per year |
|---|---|---|---|---|---|
| 1 month | -31.4% | -3.0% | −28.4 pts | ||
| 3 months | -48.0% | -2.8% | −45.2 pts | ||
| Year to date | -63.3% | +11.5% | −74.8 pts | ||
| 1 year | -58.4% | +13.5% | −71.9 pts | ||
| 3 years | -38.2% | +77.7% | −115.9 pts | -14.8% | +21.1% |
| 5 years | -11.1% | +72.6% | −83.7 pts | -2.3% | +11.5% |
| 10 years | -31.7% | +308.2% | −339.9 pts | -3.7% | +15.1% |
Short interest
Shares sold short and not yet covered, reported by brokers to FINRA twice a month. Latest settlement date Oct 30, 2026.
21M IONS shares were sold short on Oct 30, 2026, up 2.5% from the previous report, or 12.84% of the shares available to trade. At recent volumes it would take 8.4 days to buy them back. Over the last 20 sessions, 34.3% of the volume reported to FINRA was short selling.
| Settlement date | Shares short | Change | Avg. daily volume | Days to cover |
|---|---|---|---|---|
| Oct 30, 2026 | 21,165,846 | +2.5% | 2,518,244 | 8.4 |
| Oct 15, 2026 | 20,653,026 | -8.2% | 2,698,710 | 7.7 |
| Sep 30, 2026 | 22,508,744 | +7.7% | 4,881,042 | 4.6 |
| Sep 15, 2026 | 20,890,252 | -0.2% | 4,017,153 | 5.2 |
| Aug 31, 2026 | 20,924,638 | +0.1% | 2,279,069 | 9.2 |
| Aug 14, 2026 | 20,909,181 | -2.6% | 2,172,496 | 9.6 |
| Jul 31, 2026 | 21,466,123 | +7.1% | 3,382,861 | 6.3 |
| Jul 15, 2026 | 20,042,879 | +15.0% | 5,450,805 | 3.7 |
| Jun 30, 2026 | 17,425,020 | -1.9% | 2,377,735 | 7.3 |
| Jun 15, 2026 | 17,757,362 | +4.5% | 1,668,579 | 10.6 |
| May 29, 2026 | 16,986,466 | +5.6% | 1,702,170 | 10.0 |
| May 15, 2026 | 16,086,234 | -1.2% | 1,608,774 | 10.0 |
Ratios use trailing-twelve-month results and the latest balance sheet. How we calculate.
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